Effect of long-term caloric restriction on oxygen consumption and body temperature in two different strains of mice

被引:49
作者
Ferguson, Melissa
Sohal, Barbara H.
Forster, Michael J.
Sohal, Rajindar S.
机构
[1] Univ So Calif, Dept Pharmaceut Sci & Pharmacol, Los Angeles, CA 90033 USA
[2] Univ N Texas, Texas Hltl Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX 76107 USA
关键词
caloric restriction; metabolic rate; aging; life span; energy balance; obesity; inbred mice; C57BL/6; DBA/2;
D O I
10.1016/j.mad.2007.07.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The hypothesis, that a decrease in metabolic rate mediates the life span prolonging effect of caloric restriction (CR), was tested using two strains of mice, one of which, C57BL/6, exhibits life span extension as a result of CR, while the other, DBA/2, shows little or no effect. Comparisons of the rate of resting oxygen consumption, and body temperature were made between the strains after they were fed ad libitum (AL) or maintained under 40% CR, from 4 to 16 months of age. Ad libitum-fed mice of the two strains weighed the same when young and consumed similar amounts of food throughout the experiment,, however, the C5713L/6 mice weighed 25% more than DBA/2 mice at 15 months of age. The rate of oxygen consumption was normalized as per gram body weight, lean body mass or organ weight as well as per animal. The body temperature and the rate of oxygen consumption, expressed according to all of the four criteria, were decreased in the DBA/2 mice following CR. The C57BL/6 mice also showed a CR-related de crease in body temperature and in the rate of oxygen consumption per animal and when normalized according to lean body mass or organ weight. The results of this study indicate that CR indeed lowers the rate of metabolism; however, this effect by CR does not necessarily entail the prolongation of the life span of mice. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:539 / 545
页数:7
相关论文
共 40 条
[1]   Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet [J].
Andrikopoulos, S ;
Massa, CM ;
Aston-Mourney, K ;
Funkat, A ;
Fam, BC ;
Hull, RL ;
Kahn, SE ;
Proietto, J .
JOURNAL OF ENDOCRINOLOGY, 2005, 187 (01) :45-53
[2]   Energy expenditure of Rhesus monkeys subjected to 11 years of dietary restriction [J].
Blanc, S ;
Schoeller, D ;
Kemnitz, J ;
Weindruch, R ;
Colman, R ;
Newton, W ;
Wink, K ;
Baum, S ;
Ramsey, J .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (01) :16-23
[3]   Effects of dietary restriction on total body, femoral, and vertebral bone in SENCAR, C57BL/6, and DBA/2 mice [J].
Brochmann, EJ ;
Duarte, ME ;
Zaidi, HA ;
Murray, SS .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2003, 52 (10) :1265-1273
[4]   Transgenic mice with a reduced core body temperature have an increased life span [J].
Conti, Bruno ;
Sanchez-Alavez, Manuel ;
Winsky-Sommerer, Raphaelle ;
Morale, Maria Concetta ;
Lucero, Jacinta ;
Brownell, Sara ;
Fabre, Veronique ;
Huitron-Resendiz, Salvador ;
Henriksen, Steven ;
Zorrilla, Eric P. ;
de Lecea, Luis ;
Bartfai, Tamas .
SCIENCE, 2006, 314 (5800) :825-828
[5]   Effect of caloric restriction on life span of the housefly, Musca domestica [J].
Cooper, TM ;
Mockett, RJ ;
Sohal, BH ;
Sohal, RS ;
Orr, WC .
FASEB JOURNAL, 2004, 18 (11) :1591-+
[6]  
Dirkswager Edward J, 2002, Caloric restriction: A key to understanding and modulating aging
[7]   The physiologic, neurologic, and behavioral effects of caloric restriction related to aging, disease, and environmental factors [J].
Duffy, PH ;
Leakey, JEA ;
Pipkin, JL ;
Turturro, A ;
Hart, RW .
ENVIRONMENTAL RESEARCH, 1997, 73 (1-2) :242-248
[8]   INFLUENCE OF DIET ON SURVIVAL OF MICE [J].
FERNANDES, G ;
YUNIS, EJ ;
GOOD, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (04) :1279-1283
[9]   Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones [J].
Fontana, Luigi ;
Klein, Samuel ;
Holloszy, John O. ;
Premachandra, Bhartur N. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (08) :3232-3235
[10]  
FORSTER M J, 1991, Biomedical and Environmental Sciences, V4, P144