Tumor necrosis factor-alpha gene polymorphism and death due to acute cellular rejection in a subgroup of heart transplant recipients

被引：39

作者：

Azzawi, M

Hasleton, PS

Turner, DM

Yonan, N

Deiraniya, AK

Sinnott, PJ

Hutchinson, IV

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

[2] Wythenshawe Univ Hosp S Manchester, Manchester, Lancs, England

[3] N London Blood Transfus Ctr, London NW9 5BG, England

[4] Royal London Hosp, Tissue Typing Lab, London E1 1BB, England

来源：

HUMAN IMMUNOLOGY | 2001年 / 62卷 / 02期

关键词：

heart transplantation; acute rejection; TNF-alpha; gene polymorphism;

D O I：

10.1016/S0198-8859(00)00235-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Irreversible acute rejection of the transplanted heart usually has a fatal out come. Predicting which recipients are most: likely to reject might allow closer monitoring and modification of treatment protocols co prevent graft loss. Recipients generically predisposed to produce more TNF-alpha are those who suffer the most acute rejection episodes. Here we show that TNF-alpha genotype is strongly associated with death due to acute cell-mediated heart transplant rejection (Chi-square = 28.57, P < 0.0001). This subgroup of recipients should be given optimally tissue marched transplants and should be treated with the most effective immunosuppressive regimens. (C) American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.

引用

页码：140 / 142

页数：3

共 13 条

[1] TNF alpha mRNA and protein in cardiac transplant biopsies: Comparison with serum TNF alpha levels [J].