Gene Positioning

被引：54

作者：

Ferrai, Carmelo ^{[1
]}

Jesus de Castro, Ines ^{[1
]}

Lavitas, Liron ^{[1
]}

Chotalia, Mita ^{[1
]}

Pombo, Ana ^{[1
]}

机构：

[1] Imperial Coll Sch Med, MRC Clin Sci Ctr, Genome Funct Grp, London W12 0NN, England

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2010年 / 2卷 / 06期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

BETA-GLOBIN LOCUS; RNA-POLYMERASE-II; DEPENDENT SPATIAL ARRANGEMENTS; SCALE CHROMATIN ORGANIZATION; HELPER-CELL DIFFERENTIATION; LEUKEMIA NUCLEAR-BODIES; LONG-RANGE INTERACTIONS; SC-35; DOMAINS; COILED BODIES; CHROMOSOME TERRITORIES;

D O I：

10.1101/cshperspect.a000588

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotic gene expression is an intricate multistep process, regulated within the cell nucleus through the activation or repression of RNA synthesis, processing, cytoplasmic export, and translation into protein. The major regulators of gene expression are chromatin remodeling and transcription machineries that are locally recruited to genes. However, enzymatic activities that act on genes are not ubiquitously distributed throughout the nucleoplasm, but limited to specific and spatially defined foci that promote preferred higher-order chromatin arrangements. The positioning of genes within the nuclear landscape relative to specific functional landmarks plays an important role in gene regulation and disease.

引用

页数：17

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