New approach to the solid phase synthesis of N3′→P5′ phosphoramidate oligonucleotides

被引：5

作者：

Baraniak, J ^{[1
]}

Korczynski, D ^{[1
]}

Kaczmarek, R ^{[1
]}

Wasilewska, E ^{[1
]}

机构：

[1] Polish Acad Sci, Ctr Mol & Macromol Studies, Dept Bioorgan Chem, PL-90363 Lodz, Poland

来源：

NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 08期

关键词：

D O I：

10.1080/07328319808003473

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LCA-CPG-nucleoside 5'-O-(O-beta-cyanoethyl-H-phosphonates) react with 3'-amino-2',3'-dideoxynucleoside in the presence of iodine giving in a high yield N3'-->P5' phosphoramidate oligonucleotides.

引用

页码：1347 / 1353

页数：7

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