The Central Regulation of Bone Mass, The First Link between Bone Remodeling and Energy Metabolism

被引：110

作者：

Karsenty, Gerard ^{[1
]}

Oury, Franck ^{[1
]}

机构：

[1] Columbia Univ, Dept Genet & Dev, Hammer Hlth Sci Lib, New York, NY 10032 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2010年 / 95卷 / 11期

关键词：

SYMPATHETIC-NERVOUS-SYSTEM; LEPTIN REGULATION; TARGETED DISRUPTION; SEROTONIN; GENE; MICE; RECEPTOR; DENSITY; OBESITY; ANTIDEPRESSANTS;

D O I：

10.1210/jc.2010-1030

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Evolutionary consideration and clinical observations led us to hypothesize 10 yr ago that there may be a coordinated regulation, endocrine in nature, of bone remodeling and energy metabolism. The existence of this coordinated regulation is motivated by the energetic needs of the skeleton; therefore, this regulation relies on hormones that appear during evolution with the skeleton, not with energy metabolism. Leptin is such a hormone, and it is a critical regulator of bone mass as well as of appetite and energy expenditure. This review goes over the anatomical route and molecular pathways used by leptin to inhibit both bone mass accrual and appetite through its signaling in the brain. ( J Clin Endocrinol Metab 95: 4795-4801, 2010)

引用

页码：4795 / 4801

页数：7

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