The natural LewisX-bearing lipids promote membrane adhesion:: Influence of ceramide on carbohydrate-carbohydrate recognition

被引：35

作者：

Gourier, C

Pincet, F

Perez, E

Zhang, YM

Zhu, ZY

Mallet, JM

Sinay, P

机构：

[1] Ecole Normale Super, Lab Phys Stat, CNRS, UMR 8550, F-75231 Paris, France

[2] Ecole Normale Super, Dept Chim, F-75231 Paris, France

[3] Univ Paris 06, F-75231 Paris, France

[4] Univ Paris 07, F-75231 Paris, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 11期

关键词：

carbohydrates; cell adhesion; Lewis(X) determinant; lipids; vesicles;

D O I：

10.1002/anie.200461224

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Tight vesicles: Two glycosphingolipids, CerLLeX (see picture) and CerLLea (Cer = ceramide, L = lactose, LeX = LewisX determinant, Lea = Lewis a determinant) are used to study the Ca2+-mediated specific adhesion of natural LeX-bearing molecules inserted in fluid bilayer membranes. Vesicle adhesion energy experiments show that LeX-LeX recognition is highly sensitive to molecular structure. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1683 / 1687

页数：5

共 36 条

[1] CELL-ADHESION - COMPETITION BETWEEN NONSPECIFIC REPULSION AND SPECIFIC BONDING [J].