Hyaluronan as an Immune Regulator in Human Diseases

被引：865

作者：

Jiang, Dianhua ^{[1
]}

Liang, Jiurong ^{[1
]}

Noble, Paul W. ^{[1
]}

机构：

[1] Duke Univ, Sch Med, Dept Med, Div Pulm Allergy & Crit Care Med, Durham, NC 27710 USA

来源：

PHYSIOLOGICAL REVIEWS | 2011年 / 91卷 / 01期

基金：

美国国家卫生研究院;

关键词：

MESENCHYMAL STEM-CELLS; TUMOR-NECROSIS-FACTOR; SMOOTH-MUSCLE-CELLS; BRONCHOALVEOLAR LAVAGE FLUID; TOLL-LIKE RECEPTOR-4; IDIOPATHIC PULMONARY-FIBROSIS; MOLECULAR-WEIGHT HYALURONAN; ALPHA-TRYPSIN INHIBITOR; CHONDROITIN SULFATE PROTEOGLYCANS; EXTRACELLULAR-MATRIX COMPONENTS;

D O I：

10.1152/physrev.00052.2009

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Jiang D, Liang J, Noble PW. Hyaluronan as an Immune Regulator in Human Diseases. Physiol Rev 91: 221-264, 2011; doi: 10.1152/physrev.00052.2009.-Accumulation and turnover of extracellular matrix components are the hallmarks of tissue injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety of immune cells at the injury site. Hyaluronan binds to a number of cell surface proteins on various cell types. Hyaluronan fragments signal through both Toll-like receptor (TLR) 4 and TLR2 as well as CD44 to stimulate inflammatory genes in inflammatory cells. Hyaluronan is also present on the cell surface of epithelial cells and provides protection against tissue damage from the environment by interacting with TLR2 and TLR4. Hyaluronan and hyaluronan-binding proteins regulate inflammation, tissue injury, and repair through regulating inflammatory cell recruitment, release of inflammatory cytokines, and cell migration. This review focuses on the role of hyaluronan as an immune regulator in human diseases.

引用

页码：221 / 264

页数：44

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