Sleep-related hippocampo-cortical interplay during emotional memory recollection

被引：174

作者：

Sterpenich, Virginie ^{[1
]}

Albouy, Genevieve ^{[1
]}

Boly, Melanie ^{[1
]}

Vandewalle, Gilles ^{[1
]}

Darsaud, Annabelle ^{[1
]}

Balteau, Evelyne ^{[1
]}

Dang-Vu, Thien Thanh ^{[1
,2
]}

Desseilles, Martin ^{[1
,3
]}

D'Argembeau, Arnaud ^{[4
]}

Gais, Steffen ^{[1
]}

Rauchs, Geraldine ^{[1
]}

Schabus, Manuel ^{[1
,5
]}

Degueldre, Christian ^{[1
]}

Luxen, Andre ^{[1
]}

Collette, Fabienne ^{[1
,4
]}

Maquet, Pierre ^{[1
,2
]}

机构：

[1] Univ Liege, Cyclotron Res Ctr, Liege, Belgium

[2] Univ Liege, Ctr Hosp, Dept Neurol, Liege, Belgium

[3] Univ Liege, Ctr Hosp, Dept Psychiat, Liege, Belgium

[4] Univ Liege, Dept Cognit Sci, Liege, Belgium

[5] Salzburg Univ, Dept Psychol, A-5020 Salzburg, Austria

来源：

PLOS BIOLOGY | 2007年 / 5卷 / 11期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1371/journal.pbio.0050282

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Emotional events are usually better remembered than neutral ones. This effect is mediated in part by a modulation of the hippocampus by the amygdala. Sleep plays a role in the consolidation of declarative memory. We examined the impact of sleep and lack of sleep on the consolidation of emotional (negative and positive) memories at the macroscopic systems level. Using functional MRI (fMRI), we compared the neural correlates of successful recollection by humans of emotional and neutral stimuli, 72 h after encoding, with or without total sleep deprivation during the first post-encoding night. In contrast to recollection of neutral and positive stimuli, which was deteriorated by sleep deprivation, similar recollection levels were achieved for negative stimuli in both groups. Successful recollection of emotional stimuli elicited larger responses in the hippocampus and various cortical areas, including the medial prefrontal cortex, in the sleep group than in the sleep deprived group. This effect was consistent across subjects for negative items but depended linearly on individual memory performance for positive items. In addition, the hippocampus and medial prefrontal cortex were functionally more connected during recollection of either negative or positive than neutral items, and more so in sleeping than in sleep-deprived subjects. In the sleep-deprived group, recollection of negative items elicited larger responses in the amygdala and an occipital area than in the sleep group. In contrast, no such difference in brain responses between groups was associated with recollection of positive stimuli. The results suggest that the emotional significance of memories influences their sleep-dependent systems-level consolidation. The recruitment of hippocampo-neocortical networks during recollection is enhanced after sleep and is hindered by sleep deprivation. After sleep deprivation, recollection of negative, potentially dangerous, memories recruits an alternate amygdalo-cortical network, which would keep track of emotional information despite sleep deprivation.

引用

页码：2709 / 2722

页数：14

共 57 条

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