The methylenetethrahydrofolate reductase (MTHFR) C677T polymorphism and male infertility in Italy

被引：78

作者：

Stuppia, L

Gatta, V

Scarciolla, O

Colosimo, A

Guanciali-Franchi, F

Calabrese, G

Palka, G

机构：

[1] Univ G DAnnunzio, Dipartimento Sci Biomed, I-66013 Chieti, Italy

[2] CNR, Inst Normal & Pathol Cytomorphol, Chieti, Italy

[3] Civil Hosp, Serv Human Genet, Pescara, Italy

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2003年 / 26卷 / 07期

关键词：

MTHFR gene; C677T polymorphism; spermatogenesis; male infertility; folic acid;

D O I：

10.1007/BF03347018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The 677T allele of the MTHFR gene has been suggested to represent a factor of risk for male infertility. In order to confirm this association, we investigated the presence of the 677T allele in 93 Italian infertile patients, selected after the exclusion of other possible genetic causes of infertility, and in 105 Italian fertile controls. The homozygous 677TT genotype was present in 20.4% of patients and 27.6% of controls. These results do not support an association between the MTHFR 677T allele and male infertility in Italy. (C) 2003, Editrice Kurtis.

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收藏

页码：620 / 622

页数：3

相关论文

共 21 条

[1]

BENTIVOGLIO G, 1993, FERTIL STERIL, V60, P698

[2] Homozygous methylenetetrahydrofolate reductase C677T mutation and male infertility. [J].

Bezold, G ;

Lange, M ;

Peter, RU .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (15) :1172-1173

[3]

Botto LD, 2000, AM J EPIDEMIOL, V151, P862

[4] The C677T mutation of the 5,10-methylenetetrahydrofolate reductase gene is a moderate risk factor for spina bifida in Italy [J].

de Franchis, R ;

Buoninconti, A ;

Mandato, C ;

Pepe, A ;

Sperandeo, MP ;

Del Gado, R ;

Capra, V ;

Salvaggio, E ;

Andria, G ;

Mastroiacovo, P .

JOURNAL OF MEDICAL GENETICS, 1998, 35 (12) :1009-1013

[5] Infertility in men: Recent advances and continuing controversies [J].

De Kretser, DM ;

Baker, HWG .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (10) :3443-3450

[6] METHIONINE METABOLISM IN MAMMALS [J].

FINKELSTEIN, JD .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 1990, 1 (05) :228-237

[7] Biological mechanisms of male infertility [J].

Ford, WCL .

LANCET, 2001, 357 (9264) :1223-1224

[8] A CANDIDATE GENETIC RISK FACTOR FOR VASCULAR-DISEASE - A COMMON MUTATION IN METHYLENETETRAHYDROFOLATE REDUCTASE [J].

FROSST, P ;

BLOM, HJ ;

MILOS, R ;

GOYETTE, P ;

SHEPPARD, CA ;

MATTHEWS, RG ;

BOERS, GJH ;

DENHEIJER, M ;

KLUIJTMANS, LAJ ;

VANDENHEUVEL, LP ;

ROZEN, R .

NATURE GENETICS, 1995, 10 (01) :111-113

[9] Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease:: Evidence for an important genetic-environmental interaction [J].

Girelli, D ;

Friso, S ;

Trabetti, E ;

Olivieri, O ;

Russo, C ;

Pessotto, R ;

Faccini, G ;

Pignatti, PF ;

Mazzucco, A ;

Corrocher, R .

BLOOD, 1998, 91 (11) :4158-4163

[10] Genetically determined male infertility and assisted reproduction techniques [J].

Hargreave, T .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2000, 23 (10) :697-710