Synapses and growth cones on two sides of a highwire

被引：26

作者：

Fulga, Tudor A. ^{[1
,2
]}

Van Vactor, David ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA

来源：

NEURON | 2008年 / 57卷 / 03期

关键词：

D O I：

10.1016/j.neuron.2008.01.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The formation of the nervous system during embryonic development is controlled by a complex network of signaling pathways which ensure proper migration and targeting of neuronal projections. Likewise, the function of the adult nervous system relies on complex dynamic interactions between the presynaptic and postsynaptic terminals. Here, we review recent advances in understanding the molecular pathways underlying these seemingly distinct processes. These studies reveal that the conserved E3 ubiquitin ligase PHR (PAM, highwire Rpm-1) controls a regulatory protein degradation pathway essential both for axonal targeting during embryonic development as well as for the proper formation and function of neuron muscular junctions (NMJ).

引用

页码：339 / 344

页数：6

共 35 条

[1]

Berman Kevin, 2001, Molecular Cell Biology Research Communications, V4, P337, DOI 10.1006/mcbr.2001.0300

[2] The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons [J].

Bloom, A. Joseph ;

Miller, Bradley R. ;

Sanes, Joshua R. ;

DiAntonio, Aaron .

GENES & DEVELOPMENT, 2007, 21 (20) :2593-2606

[3] Specification of neuronal fates in the ventral neural tube [J].

Briscoe, J ;

Ericson, J .

CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (01) :43-49

[4]

BROWN A, 1993, J CELL SCI, V104, P339

[5] Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice [J].

Burgess, RW ;

Peterson, KA ;

Johnson, MJ ;

Roix, JJ ;

Welsh, IC ;

O'Brien, TP .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (03) :1096-1105

[6] highwire, rpm-1, and futsch:: Balancing synaptic growth and stability [J].

Chang, Q ;

Balice-Gordon, RJ .

NEURON, 2000, 26 (02) :287-290

[7] Highwire restrains synaptic growth by attenuating a MAP kinase signal [J].

Collins, Catherine A. ;

Wairkar, Yogesh P. ;

Johnson, Sylvia L. ;

DiAntonio, Aaron .

NEURON, 2006, 51 (01) :57-69

[8] Formation of the retinotectal projection requires Esrom, an ortholog of PAM (protein associated with Myc) [J].

D'Souza, J ;

Hendricks, M ;

Le Guyader, S ;

Subburaju, S ;

Grunewald, B ;

Scholich, K ;

Jesuthasan, S .

DEVELOPMENT, 2005, 132 (02) :247-256

[9] SCF and cullin/RING H2-based ubiquitin ligases [J].

Deshaies, RJ .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 :435-467

[10] Ubiquitination-dependent mechanisms regulate synaptic growth and function [J].

DiAntonio, A ;

Haghighi, AP ;

Portman, SL ;

Lee, JD ;

Amaranto, AM ;

Goodman, CS .

NATURE, 2001, 412 (6845) :449-452

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