Glutathionylation pathways in drug response

被引：45

作者：

Ghezzi, Pietro ^{[1
]}

Di Sirnplicio, Paolo

机构：

[1] Mario Negri Inst Pharmacol Res, Lab Neuroimmunol, I-20157 Milan, Italy

[2] Univ Siena, Dept Neurosci, I-53100 Siena, Italy

来源：

CURRENT OPINION IN PHARMACOLOGY | 2007年 / 7卷 / 04期

关键词：

D O I：

10.1016/j.coph.2007.04.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Regulation of protein function through post-translational modifications (PTM) can be important pharmacological target, and there are drugs developed to modulate specific PTM such as protein kinase or histone deacetylase inhibitors. We are still far behind in considering protein glutathionylation as pharmacological target as the biological consequences and role of this PTM are still unclear. We discuss the possible relevance of glutathionylation in diseases and its biases compared with other PTM. In particular, we discuss the different roles of glutathionylation in the context of redox regulation as opposed to that of oxidative stress, and the difficulties arising from the overlaps of these two concepts.

引用

页码：398 / 403

页数：6

共 30 条

[1] S-THIOLATION OF INDIVIDUAL HUMAN NEUTROPHIL PROTEINS INCLUDING ACTIN BY STIMULATION OF THE RESPIRATORY BURST - EVIDENCE AGAINST A ROLE FOR GLUTATHIONE DISULFIDE [J].

CHAI, YC ;

ASHRAF, SS ;

ROKUTAN, K ;

JOHNSTON, RB ;

THOMAS, JA .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1994, 310 (01) :273-281

[2] CHEMICAL-REACTIVITY OF SOME ISOTHIAZOLONE BIOCIDES [J].

COLLIER, PJ ;

RAMSEY, A ;

WAIGH, RD ;

DOUGLAS, KT ;

AUSTIN, P ;

GILBERT, P .

JOURNAL OF APPLIED BACTERIOLOGY, 1990, 69 (04) :578-584

[3] Actin S-glutathionylation:: Eidence against a thiol-disulphide exchange mechanism [J].

Dalle-Donne, I ;

Rossi, R ;

Giustarini, D ;

Colombo, R ;

Milzani, A .

FREE RADICAL BIOLOGY AND MEDICINE, 2003, 35 (10) :1185-1193

[4] On the functional interchangeability, oxidant versus reductant, of members of the thioredoxin superfamily [J].

Debarbieux, L ;

Beckwith, J .

JOURNAL OF BACTERIOLOGY, 2000, 182 (03) :723-727

[5] The effects of age and hyperhomocysteinemia on the redox forms of plasma thiols [J].

Di Giuseppe, D ;

Frosali, S ;

Priora, R ;

Di Simplicio, FC ;

Buonocore, G ;

Cellesi, C ;

Capecchi, PL ;

Pasini, FL ;

Lazzerini, PE ;

Jakubowski, H ;

Di Simplicio, P .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2004, 144 (05) :235-245

[6] Role of protein -SH groups in redox homeostasis - The erythrocyte as a model system [J].

Di Simplicio, P ;

Cacace, MG ;

Lusini, L ;

Giannerini, F ;

Giustarini, D ;

Rossi, R .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1998, 355 (02) :145-152

[7] GSH depletion, protein S-glutathionylation and mitochondrial transmembrane potential hyperpolarization are early events in initiation of cell death induced by a mixture of isothiazolinones in HL60 cells [J].

Di Stefano, A ;

Frosali, S ;

Leonini, A ;

Ettorre, A ;

Priora, R ;

Di Simplicio, FC ;

Di Simplicio, P .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2006, 1763 (02) :214-225

[8] Glyceraldehyde phosphate dehydrogenase oxidation during cardiac ischemia and reperfusion [J].

Eaton, P ;

Wright, N ;

Hearse, DJ ;

Shattock, MJ .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2002, 34 (11) :1549-1560

[9] A novel role for human sulfiredoxin in the reversal of glutathionylation [J].

Findlay, Victoria J. ;

Townsend, Danyelle M. ;

Morris, Taylor E. ;

Fraser, Jacob P. ;

He, Lin ;

Tew, Kenneth D. .

CANCER RESEARCH, 2006, 66 (13) :6800-6806

[10] Gene expression profiling reveals a signaling role of glutathione in redox regulation [J].

Fratelli, M ;

Goodwin, LO ;

Orom, UA ;

Lombardi, S ;

Tonelli, R ;

Mengozzi, M ;

Ghezzi, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (39) :13998-14003

← 1 2 3 →