Adult stem cells and tissue repair

被引：46

作者：

Körbling, M

Estrov, Z

Champlin, R

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Unit 423, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Immunotherapy, Houston, TX 77030 USA

来源：

BONE MARROW TRANSPLANTATION | 2003年 / 32卷

关键词：

adult stem cells; developmental stem cell plasticity; stem cell transdifferentiation; regenerative medicine; BONE-MARROW; HEPATOCYTES; FUSION;

D O I：

10.1038/sj.bmt.1703939

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Recently, adult stem cells originating from bone marrow or peripheral blood have been suggested to contribute to repair and genesis of cells specific for liver, cardiac and skeletal muscle, gut, and brain tissue. The mechanism involved has been termed transdifferentiation, although other explanations including cell fusion have been postulated. Using adult stem cells to generate or repair solid organ tissue obviates the immunologic, ethical, and teratogenic issues that accompany embryonic stem cells.

引用

收藏

页码：S23 / S24

页数：2

相关论文

共 13 条

[1] Cell differentiation - Hepatocytes from nonhepatic adult stem cells [J].

Alison, MR ;

Poulsom, R ;

Jeffery, R ;

Dhillon, AP ;

Quaglia, A ;

Jacob, J ;

Novelli, M ;

Prentice, G ;

Williamson, J ;

Wright, NA .

NATURE, 2000, 406 (6793) :257-257

[2] Horizontal transfer of DNA and the "genometastasis hypothesis" [J].

García-Olmo, D ;

García-Olmo, D ;

Ontañón, J ;

Martinez, E .

BLOOD, 2000, 95 (02) :724-725

[3] Absence of donor-derived keratinocyte stem cells in skin tissues cultured from patients after mobilized peripheral blood hematopoietic stem cell transplantation [J].

Hematti, P ;

Sloand, EM ;

Carvallo, CA ;

Albert, MR ;

Yee, CL ;

Fuehrer, MM ;

Blancato, JK ;

Kearns, WG ;

Barrett, JA ;

Childs, RW ;

Vogel, JC ;

Dunbar, CE .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (08) :943-949

[4] Pluripotency of mesenchymal stem cells derived from adult marrow [J].

Jiang, Yuehua ;

Jahagirdar, Balkrishna N. ;

Reinhardt, R. Lee ;

Schwartz, Robert E. ;

Keene, C. Dirk ;

Ortiz-Gonzalez, Xilma R. ;

Reyes, Morayma ;

Lenvik, Todd ;

Lund, Troy ;

Blackstad, Mark ;

Du, Jingbo ;

Aldrich, Sara ;

Lisberg, Aaron ;

Low, Walter C. ;

Lergaespada, David A. ;

Verfaillie, Catherine M. .

Nature, 2002, 418 (6893) :41-49

[5] Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. [J].

Korbling, M ;

Katz, RL ;

Khanna, A ;

Ruifrok, AC ;

Rondon, G ;

Albitar, M ;

Champlin, RE ;

Estrov, Z .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (10) :738-746

[6] Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell [J].

Krause, DS ;

Theise, ND ;

Collector, MI ;

Henegariu, O ;

Hwang, S ;

Gardner, R ;

Neutzel, S ;

Sharkis, SJ .

CELL, 2001, 105 (03) :369-377

[7] Purified hematopoietic stem cells can differentiate into hepatocytes in vivo [J].

Lagasse, E ;

Connors, H ;

Al-Dhalimy, M ;

Reitsma, M ;

Dohse, M ;

Osborne, L ;

Wang, X ;

Finegold, M ;

Weissman, IL ;

Grompe, M .

NATURE MEDICINE, 2000, 6 (11) :1229-1234

[8] Dedifferentiation of mammalian myotubes induced by msx1 [J].

Odelberg, SJ ;

Kollhoff, A ;

Keating, MT .

CELL, 2000, 103 (07) :1099-1109

[9] Mobilized bone marrow cells repair the infarcted heart, improving function and survival [J].

Orlic, D ;

Kajstura, J ;

Chimenti, S ;

Limana, F ;

Jakoniuk, I ;

Quaini, F ;

Nadal-Ginard, B ;

Bodine, DM ;

Leri, A ;

Anversa, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10344-10349

[10] Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion [J].

Terada, N ;

Hamazaki, T ;

Oka, M ;

Hoki, M ;

Mastalerz, DM ;

Nakano, Y ;

Meyer, EM ;

Morel, L ;

Petersen, BE ;

Scott, EW .

NATURE, 2002, 416 (6880) :542-545