Postantibiotic effect and postantibiotic sub-MIC effect of quinupristin-dalfopristin against Gram-positive and -negative organisms

被引：16

作者：

Pankuch, GA

Jacobs, MR

Appelbaum, PC

机构：

[1] Penn State Univ, Milton S Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA

[2] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 11期

关键词：

D O I：

10.1128/AAC.42.11.3028

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Quinupristin-dalfopristin produced postantibiotic effects (PAEs) and postantibiotic sub-MIG effects of >2 h against 18 gram-positive cocci. Mean pneumococcal and staphylococcal PAEs were 2.8 and 4.7 h, respectively, with shorter PAEs for constitutively than inducibly macrolide-resistant staphylococci. Mean PAEs for vancomycin-susceptible and -resistant Enterococcus faecium were 8.5 and 2.6 h, respectively.

引用

收藏

页码：3028 / 3031

页数：4

相关论文

共 16 条

[1] Distribution of genes encoding resistance to streptogramin A and related compounds among staphylococci resistant to these antibiotics [J].

Allignet, J ;

Aubert, S ;

Morvan, A ;

ElSolh, N .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (11) :2523-2528

[2] The pharmacokinetics of quinupristin/dalfopristin in laboratory animals and in humans [J].

Bergeron, M ;

Montay, G .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 39 :129-138

[3] THE POSTANTIBIOTIC EFFECT OF RP-59500 ON STAPHYLOCOCCUS-AUREUS INCLUDING STRAINS WITH A RAISED MBC [J].

BOSWELL, FJ ;

ANDREWS, JM ;

WISE, R .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 33 (06) :1219-1222

[4] INVITRO ACTIVITY OF RP 59500, A NEW SEMISYNTHETIC STREPTOGRAMIN ANTIBIOTIC, AGAINST GRAM-POSITIVE BACTERIA [J].

BRUMFITT, W ;

HAMILTONMILLER, JMT ;

SHAH, S .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1992, 30 :29-37

[5] POSTANTIBIOTIC EFFECT OF THE NEW STREPTOGRAMIN-RP-59500 [J].

CHIN, NX ;

NEU, HC .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1992, 11 (07) :642-645

[6] INVITRO ACTIVITY OF RP59500, AN INJECTABLE STREPTOGRAMIN ANTIBIOTIC, AGAINST VANCOMYCIN-RESISTANT GRAM-POSITIVE ORGANISMS [J].

COLLINS, LA ;

MALANOSKI, GJ ;

ELIOPOULOS, GM ;

WENNERSTEIN, CB ;

FERRARO, MJ ;

MOELLERING, RC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (03) :598-601

[7]

Craig WA, 1996, ANTIBIOTICS LAB MED, P296

[8] A PHASE-I, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF THE TOLERANCE AND PHARMACOKINETIC BEHAVIOR OF RP 59500 [J].

ETIENNE, SD ;

MONTAY, G ;

LELIBOUX, A ;

FRYDMAN, A ;

GARAUD, JJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1992, 30 :123-131

[9] BACTERIAL-RESISTANCE TO MACROLIDE, LINCOSAMIDE, AND STREPTOGRAMIN ANTIBIOTICS BY TARGET MODIFICATION [J].

LECLERCQ, R ;

COURVALIN, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (07) :1267-1272

[10]

*NAT COMM CLIN LAB, 1996, NCCLS PUBL