Are juvenile pilocytic astrocytomas benign tumors? A cytogenetic study in 24 cases

被引：36

作者：

Zattara-Cannoni, H

Gambarelli, D

Lena, G

Dufour, H

Choux, M

Grisoli, F

Vagner-Capodano, AM

机构：

[1] CHU Timone, Cytogenet Oncol Lab, F-13385 Marseille 05, France

[2] CHU Timone, Pathol & Neuropathol Lab, F-13385 Marseille, France

[3] CHU Timone, Dept Neurosurg, F-13385 Marseille 05, France

来源：

CANCER GENETICS AND CYTOGENETICS | 1998年 / 104卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(97)00455-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We performed a cytogenetic study on 24 pilocytic astrocytomas: 23 in children and 1 in a young adult. We observed 12 normal karyotypes. In 12 karyotypes with structural and/or numerical abnormalities, chromosomes 7, 8, and 11 were most frequently involved. One case recurred and presented chromosomal abnormalities (hyperdiploidy) in the first tumor and additional structural abnormalities in the second tumor. We believe that chromosomal abnormalities in pilocytic astrocytomas are frequent and indicate tumoral progression. (C) Elsevier Science Inc., 1998.

引用

页码：157 / 160

页数：4

共 21 条

[1] CHROMOSOMAL-ABNORMALITIES IN 47 PEDIATRIC BRAIN-TUMORS [J].

AGAMANOLIS, DP ;

MALONE, AM .

CANCER GENETICS AND CYTOGENETICS, 1995, 81 (02) :125-134

[2] GENE AMPLIFICATION IN MALIGNANT HUMAN GLIOMAS - CLINICAL AND HISTOPATHOLOGIC ASPECTS [J].

BIGNER, SH ;

BURGER, PC ;

WONG, AJ ;

WERNER, MH ;

HAMILTON, SR ;

MUHLBAIER, LH ;

VOGELSTEIN, B ;

BIGNER, DD .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1988, 47 (03) :191-205

[3] TP53 GENE-MUTATIONS AND 17P DELETIONS IN HUMAN ASTROCYTOMAS [J].

CHUNG, R ;

WHALEY, J ;

KLEY, N ;

ANDERSON, K ;

LOUIS, DN ;

MENON, A ;

HETTLICH, C ;

FREIMAN, R ;

HEDLEYWHYTE, ET ;

MARTUZA, R ;

JENKINS, R ;

YANDELL, D ;

SEIZINGER, BR .

GENES CHROMOSOMES & CANCER, 1991, 3 (05) :323-331

[4]

DUTRILLAUX B, 1971, CR ACAD SCI D NAT, V272, P2638

[5]

GANJU V, 1994, CANCER-AM CANCER SOC, V74, P920, DOI 10.1002/1097-0142(19940801)74:3<920::AID-CNCR2820740320>3.0.CO

[6]

2-4

[7] TRISOMY-7 AND SEX-CHROMOSOME LOSS IN HUMAN BRAIN-TISSUE [J].

HEIM, S ;

MANDAHL, N ;

JIN, Y ;

STROMBLAD, S ;

LINDSTROM, E ;

SALFORD, LG ;

MITELMAN, F .

CYTOGENETICS AND CELL GENETICS, 1989, 52 (3-4) :136-138

[8]

JAMES CD, 1988, CANCER RES, V48, P5546

[9] A CYTOGENETIC STUDY OF 53 HUMAN GLIOMAS [J].

JENKINS, RB ;

KIMMEL, DW ;

MOERTEL, CA ;

SCHULTZ, CG ;

SCHEITHAUER, BW ;

KELLY, PJ ;

DEWALD, GW .

CANCER GENETICS AND CYTOGENETICS, 1989, 39 (02) :253-279

[10] CYTOGENETIC ANALYSIS OF 39 PEDIATRIC CENTRAL-NERVOUS-SYSTEM TUMORS [J].

KARNES, PS ;

TRAN, TN ;

CUI, MY ;

RAFFEL, C ;

GILLES, FH ;

BARRANGER, JA ;

YING, KL .

CANCER GENETICS AND CYTOGENETICS, 1992, 59 (01) :12-19

← 1 2 3 →