Cardiac Baroreflex Sensitivity Is Not Correlated to Sympathetic Baroreflex Sensitivity Within Healthy, Young Humans

被引：55

作者：

Dutoit, Andrea P. ^{[1
]}

Hart, Emma C. ^{[1
]}

Charkoudian, Nisha ^{[2
]}

Wallin, B. Gunnar ^{[3
]}

Curry, Timothy B. ^{[1
]}

Joyner, Michael J. ^{[1
]}

机构：

[1] Mayo Clin, Dept Anesthesiol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA

[3] Gothenburg Univ, Inst Neurosci & Physiol, Sahlgren Acad, Gothenburg, Sweden

来源：

HYPERTENSION | 2010年 / 56卷 / 06期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

baroreflex sensitivity; sympathetic; cardiac; sex differences;

D O I：

10.1161/HYPERTENSIONAHA.110.158329

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The purpose of this study was to evaluate the relationship between the cardiac and sympathetic baroreflex sensitivities within healthy, young humans. The sensitivities of the cardiac and sympathetic baroreflexes were compared in 53 normotensive individuals (28 men and 25 women; age: 24.0 +/- 0.9 years; body mass index: 24.0 +/- 0.3 cm/kg(2), mean +/- SEM). Heart rate, arterial blood pressure, and peroneal muscle sympathetic nerve activity were recorded under resting conditions (heart rate: 58 +/- 1 bpm; systolic blood pressure: 126 +/- 2 mm Hg; diastolic blood pressure: 72 +/- 1 mm Hg; mean arterial blood pressure: 89 +/- 1 mm Hg; muscle sympathetic nerve activity: 18 +/- 1 bursts per min) and during rapid changes in blood pressure induced by sequential boluses of nitroprusside and phenylephrine. Cardiac and sympathetic baroreflex sensitivities were analyzed using the slopes of the linear portions of the muscle sympathetic nerve activity-diastolic blood pressure and R-R interval-systolic blood pressure relationships, respectively. When individual cardiac baroreflex sensitivity was compared with sympathetic baroreflex sensitivity, no correlation (R-R interval: r=-0.13; heart rate: r=0.21) was observed when studied as a group. Analysis by sex unveiled a correlation in women between the cardiac and sympathetic baroreflex sensitivities (R-R interval: r=-0.54; P=0.01; no correlation with hazard ratio: r=0.29). No relationship was found in men (R-R interval: r=0.17; heart rate: r=0.12). These results indicate that, although both cardiac and sympathetic efferents function in baroreflex control of arterial pressure, there is no correlation in their sensitivities within healthy normotensive humans. However, sex-stratified data indicate that sex-based differential correlations might exist. (Hypertension. 2010;56:1118-1123.)

引用

页码：1118 / 1123

页数：6

共 34 条

[1]

La Rovere M.T., Pinna G.D., Raczak G., Baroreflex sensitivity: Measurement and clinical implications, Ann Noninvasive Electrocardiol, 13, pp. 191-207, (2008)

[2]

Charkoudian N., Martin E.A., Dinenno F.A., Eisenach J.H., Dietz N.M., Joyner M.J., Influence of increased central venous pressure on baroreflex control of sympathetic activity in humans, Am J Physiol Heart Circ Physiol, 287, (2004)

[3]

Cui J., Wilson T.E., Crandall C.G., Baroreflex modulation of muscle sympathetic nerve activity during cold pressor test in humans, American Journal of Physiology - Heart and Circulatory Physiology, 282, 5, (2002)

[4]

O'Leary D.D., Kimmerly D.S., Cechetto A.D., Shoemaker J.K., Differential effect of head-up tilt on cardiovagal and sympathetic baroreflex sensitivity in humans, Exp Physiol, 88, pp. 769-774, (2003)

[5]

Rudas L., Crossman A.A., Morillo C.A., Halliwill J.R., Tahvanainen K.U., Kuusela T.A., Eckberg D.L., Human sympathetic and vagal baroreflex responses to sequential nitroprusside and phenylephrine, Am J Physiol, 276, (1999)

[6]

Matsukawa T., Sugiyama Y., Mano T., Age-related changes in baroreflex control of heart rate and sympathetic nerve activity in healthy humans, J Auton Nerv Syst, 60, pp. 209-212, (1996)

[7]

Christou D.D., Jones P.P., Jordan J., Diedrich A., Robertson D., Seals D.R., Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men, Circulation, 111, pp. 494-498, (2005)

[8]

Hart E.C., Charkoudian N., Wallin B.G., Curry T.B., Eisenach J.H., Joyner M.J., Sex differences in sympathetic neural-hemodynamic balance: Implications for human blood pressure regulation, Hypertension, 53, pp. 571-576, (2009)

[9]

Saleh T.M., Connell B.J., Saleh M.C., Acute injection of 17/3-estradiol enhances cardiovascular reflexes and autonomic tone in ovariectomized female rats, Auton Neurosci, 84, pp. 78-88, (2000)

[10]

Charkoudian N., Halliwill J.R., Morgan B.J., Eisenach J.H., Joyner M.J., Influences of hydration on post-exercise cardiovascular control in humans, J Physiol, 552, pp. 635-644, (2003)

← 1 2 3 4 →