Human genetic variation and the gut microbiome in disease

被引：411

作者：

Hall, Andrew Brantley ^{[1
,2
,3
]}

Tolonen, Andrew C. ^{[1
]}

Xavier, Ramnik J. ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Broad Inst Massachusetts Inst Technol & Harvard U, Cambridge, MA 02142 USA

[2] Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA

[3] Harvard Med Sch, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USA

[5] Massachusetts Gen Hosp, Ctr Study Inflammatory Bowel Dis, Boston, MA 02114 USA

[6] MIT, Ctr Microbiome Informat & Therapeut, Cambridge, MA 02139 USA

来源：

NATURE REVIEWS GENETICS | 2017年 / 18卷 / 11期

关键词：

INFLAMMATORY-BOWEL-DISEASE; GENOME-WIDE ASSOCIATION; INVASIVE ESCHERICHIA-COLI; BODY-MASS INDEX; CROHNS-DISEASE; AKKERMANSIA-MUCINIPHILA; HOST GENETICS; BACTEROIDES-FRAGILIS; INTESTINAL-TRACT; MUCIN;

D O I：

10.1038/nrg.2017.63

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Taxonomic and functional changes to the composition of the gut microbiome have been implicated in multiple human diseases. Recent microbiome genome-wide association studies reveal that variants in many human genes involved in immunity and gut architecture are associated with an altered composition of the gut microbiome. Although many factors can affect the microbial organisms residing in the gut, a number of recent findings support the hypothesis that certain host genetic variants predispose an individual towards microbiome dysbiosis. This condition, in which the normal microbiome population structure is disturbed, is a key feature in disorders of metabolism and immunity.

引用

页码：690 / 699

页数：10

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