Enhanced intramolecular amide-amide hydrogen bonding through cooperativity

被引：21

作者：

Gung, BW

Zhu, ZH

机构：

[1] Department of Chemistry, Miami University, Oxford

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 13期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(96)00256-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Model peptides 1-6 are prepared and studied by IR and variable temperature H-1 NMR spectroscopies. The alpha-hydroxy diamides 3 and 4 form intramolecular amide-amide hydrogen bond through an eight-membered and a nine-membered ring, respectively. When compared to Gellman's simple diamides of same chain length, the enhanced hydrogen bond strength is considered as an indication of a cooperative effect.

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页码：2189 / 2192

页数：4

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