Adiponectin and bone mass density The InCHIANTI study

Introduction Adiponectin serum concentration has been reported to be inversely correlated with bone mineral density (BMD) in humans The data on this Issue however are biased by small study sample size and lack of controlling for body composition Methods We used data from the third follow-up of the InCHIANTI study which included measurements of BMD using quantitative CT of the tibia and of body composition using bioimpedenziometry Serum adiponectin was measured using radioimmunoassay We excluded participants with diabetes hyperthyroidism using hormone replacement or corticosteroid therapy We evaluated the correlation of adiponectin with total trabecular and cortical BMD using Pearson s coefficient and linear regression models to estimate the association between adiponectin and BMD controlling for potential confounders (age body mass index alcohol intake fat mass smoking) Results Our sample was made up of 320 men (mean age 67 years SD 158 range 29-97 years) and 271 postmenopausal women (mean age 76 years SD 82 range 42-97 years) In men serum adiponectin was not independently associated with BMD In women after correction for potential confounders adiponectin was associated with total (beta= -0626 P<0 001) trabecular (beta= -0696 P<0 001) and cortical (beta= -1076 P=0001) BMD Conclusion Our results show that adiponectin is Inversely associated with bone mass in women Further studies are needed to confirm these findings prospectively and then to clarify the explanatory mechanisms (C) 2010 Elsevier Inc All rights reserved