Tissue-specific regulation of mouse MicroRNA genes in endoderm-derived tissues

被引：51

作者：

Gao, Yan ^{[3
]}

Schug, Jonathan ^{[1
,2
]}

McKenna, Lindsay B. ^{[1
,2
]}

Le Lay, John ^{[1
,2
]}

Kaestner, Klaus H. ^{[1
,2
]}

Greenbaum, Linda E. ^{[4
,5
]}

机构：

[1] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

[4] Thomas Jefferson Univ, Jefferson Med Coll, Dept Canc Biol, Philadelphia, PA 19107 USA

[5] Thomas Jefferson Univ, Jefferson Med Coll, Dept Med, Philadelphia, PA 19107 USA

来源：

NUCLEIC ACIDS RESEARCH | 2011年 / 39卷 / 02期

基金：

美国国家卫生研究院;

关键词：

FOXA2; HEPATOCYTE; EXPRESSION; CELLS; LIVER; NETWORKS; GENOME; STATE;

D O I：

10.1093/nar/gkq782

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

MicroRNAs fine-tune the activity of hundreds of protein-coding genes. The identification of tissue-specific microRNAs and their promoters has been constrained by the limited sensitivity of prior microRNA quantification methods. Here, we determine the entire microRNAome of three endoderm-derived tissues, liver, jejunum and pancreas, using ultra-high throughput sequencing. Although many microRNA genes are expressed at comparable levels, 162 microRNAs exhibited striking tissue-specificity. After mapping the putative promoters for these microRNA genes using H3K4me3 histone occupancy, we analyzed the regulatory modules of 63 microRNAs differentially expressed between liver and jejunum or pancreas. We determined that the same transcriptional regulatory mechanisms govern tissue-specific gene expression of both mRNA and microRNA encoding genes in mammals.

引用

页码：454 / 463

页数：10

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