No association of breast cancer risk with integrin beta3 (ITGB3) Leu33Pro genotype

被引：10

作者：

Bojesen, SE

Tybjærg-Hansen, A

Axelsson, CK

Nordestgaard, BG

机构：

[1] Herlev Univ Hosp, Dept Clin Biochem, DK-2730 Herlev, Denmark

[2] Bispebjerg Univ Hosp, Copenhagen City Heart Study, DK-2400 Copenhagen, Denmark

[3] Univ Copenhagen Hosp, Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark

[4] Herlev Univ Hosp, Dept Breast Surg, DK-2730 Herlev, Denmark

来源：

BRITISH JOURNAL OF CANCER | 2005年 / 93卷 / 01期

关键词：

integrins; breast cancer; genetic polymorphism; genetic epidemiology; case-control;

D O I：

10.1038/sj.bjc.6602674

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To pursue a borderline increased risk of breast cancer for carriers of two integrin beta3 (ITGB3) 33Pro alleles found in a recent prospective study, we conducted a case - control study of 1088 women with breast cancer and 4815 female controls. Leu33Pro heterozygotes, homozygotes and heterozygotes + homozygotes vs noncarriers had odds ratios for breast cancer of 1.0 (95% confidence interval: 0.8 - 1.1), 0.8 (0.5 - 1.2) and 1.0 ( 0.8 - 1.1), respectively. After stratification for conventional risk factors, odds ratio for breast cancer in heterozygotes, homozygotes and heterozygotes + homozygotes vs noncarriers were not increased above 1.0 in any of the 14 strata examined. This was also true after stratification for tumour histological subtype and cancer stage at the time of diagnosis.

引用

页码：167 / 171

页数：5

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