Therapeutic ultrasound for gene delivery

被引：37

作者：

Porter, TR ^{[1
]}

Xie, F ^{[1
]}

机构：

[1] Univ Nebraska, Med Ctr, Nebraska Med Ctr 981165, Omaha, NE 68198 USA

来源：

ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES | 2001年 / 18卷 / 04期

关键词：

ultrasound; gene therapy; oligonucleotides; PESDA; microbubbles;

D O I：

10.1046/j.1540-8175.2001.00349.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In vitro and in vivo studies using perfluorocarbon-exposed sonicated dextrose albumin (PESDA) microbubbles to enhance gene delivery are reviewed. lit vitro studies show PESDA binds to oligonucleotides and that ultrasound can, be used to deposit these nucleotides. In addition, in vitro studies show that drug release from microspheres is dependent on ultrasound transmission frequency as well as pulsed or continuous application. Early in vivo studies confirm that ultrasound in, combination with microbubbles can be used to facilitate gene deposition. However the role of ultrasound targeting gene delivery remains to be determined.

引用

页码：349 / 353

页数：5

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