Studies of the "smart" thermoresponsive behavior of copolymers of N-isopropylacrylamide and N,N-dimethylacrylamide in dilute aqueous solution

被引:113
作者
Barker, IC
Cowie, JMG
Huckerby, TN
Shaw, DA
Soutar, I [1 ]
Swanson, L
机构
[1] Univ Sheffield, Ctr Polymer, Sheffield S3 7HF, S Yorkshire, England
[2] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
[3] Heriot Watt Univ, Dept Chem, Edinburgh EH14 4AS, Midlothian, Scotland
[4] Daresbury Lab, CLRC, SRS, Warrington WA4 4AD, Cheshire, England
[5] Univ Lancaster, Sch Phys & Chem, Lancaster LA1 4YA, England
关键词
D O I
10.1021/ma034250m
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Various fluorescence techniques and cloud point measurements have been used to study the effects of altering the hydrophilic/hydrophobic balance in a series of N-isopropylacrylamide (NIPAM)/ N,N-dimethylacrylamide (DMAC) statistical copolymers upon the smart thermal responses of these systems in dilute aqueous solution. As expected, incorporation of DMAC into the polymer structure raises its lower critical solution temperature to an extent dependent upon DMAC content. However, use of such a hydrophilic modifier reduces the magnitude of the collapse transition that characterizes the macromolecule's thermal response. In PNIPAM, the LCST is associated with a conformational transition between a coil and a globule. However, introduction of DMAC derivatives into the polymer expands its "globular" form into a much more open structure that progressively loses its capacity for solubilization of organic guests. Consequently, although copolymerization with more polar monomers can be used to raise the LCST of NIPAM-based thermoresponsive polymers, the value of this approach will be limited in applications requiring switchable carrier/release properties.
引用
收藏
页码:7765 / 7770
页数:6
相关论文
共 32 条
[1]  
Bu''nau G. v., 1970, RANG DALESPHARMACOLO, V74, P1294, DOI [10.1002/bbpc.19700741223, DOI 10.1002/BBPC.19700741223]
[2]   Time-resolved fluorescence studies of the interactions between the thermoresponsive polymer host, poly(N-isopropylacrylamide), and a hydrophobic guest, pyrene [J].
Chee, CK ;
Ghiggino, KP ;
Smith, TA ;
Rimmer, S ;
Soutar, I ;
Swanson, L .
POLYMER, 2001, 42 (05) :2235-2240
[3]   Time-resolved fluorescence anisotropy studies of the temperature-induced intramolecular conformational transition of poly(N-isopropylacrylamide) in dilute aqueous solution [J].
Chee, CK ;
Rimmer, S ;
Soutar, I ;
Swanson, L .
POLYMER, 1997, 38 (02) :483-486
[4]   Manipulating the thermoresponsive behavior of poly(N-isopropylacrylamide).: 1.: On the conformational behavior of a series of N-isopropylacrylamide -: Styrene statistical copolymers [J].
Chee, CK ;
Rimmer, S ;
Shaw, DA ;
Soutar, I ;
Swanson, L .
MACROMOLECULES, 2001, 34 (21) :7544-7549
[5]   Luminescence studies of hydrophobically modified, water-soluble polymers .1. Fluorescence anisotropy and spectroscopic investigations of the conformational behaviour of copolymers of acrylic acid and styrene or methyl methacrylate [J].
Ebdon, JR ;
Hunt, BJ ;
Lucas, DM ;
Soutar, I ;
Swanson, L ;
Lane, AR .
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1995, 73 (11) :1982-1994
[6]   EFFECT OF COMONOMER HYDROPHILICITY AND IONIZATION ON THE LOWER CRITICAL SOLUTION TEMPERATURE OF N-ISOPROPYLACRYLAMIDE COPOLYMERS [J].
FEIL, H ;
BAE, YH ;
FEIJEN, J ;
KIM, SW .
MACROMOLECULES, 1993, 26 (10) :2496-2500
[7]   Fluorescence investigations of "smart" microgel systems [J].
Flint, NJ ;
Gardebrecht, S ;
Swanson, L .
JOURNAL OF FLUORESCENCE, 1998, 8 (04) :343-353
[8]   PHASE-TRANSITION OF AQUEOUS-SOLUTIONS OF POLY(N-ISOPROPYLACRYLAMIDE) AND POLY(N-ISOPROPYLMETHACRYLAMIDE) [J].
FUJISHIGE, S ;
KUBOTA, K ;
ANDO, I .
JOURNAL OF PHYSICAL CHEMISTRY, 1989, 93 (08) :3311-3313
[9]  
HUNDSON CS, 1904, Z PHYS CHEM, V47, P8
[10]   PHASE-TRANSITION OF N-SUBSTITUTED ACRYLAMIDE GELS [J].
INOMATA, H ;
GOTO, S ;
SAITO, S .
MACROMOLECULES, 1990, 23 (22) :4887-4888