The best structural model of ADH so far: a pyrazolylbis(thioimidazolyl)borate zinc ethanol complex

被引：51

作者：

Seebacher, J ^{[1
]}

Shu, MH ^{[1
]}

Vahrenkamp, H ^{[1
]}

机构：

[1] Univ Freiburg, Inst Anorgan & Analyt Chem, D-79104 Freiburg, Germany

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 11期

关键词：

D O I：

10.1039/b100281n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The new N,S,S ligand [HB(tim(o-An))(2)(pz(Ph,Me))](-) (L-1) was combined with zinc perchlorate and ethanol to form the complex [L-1.Zn(ethanol)]ClO4 which is the first zinc complex in which the N,S,S ligation of zinc and the attachment of ethanol occurring in the active center of horse liver alcoholdehydrogenase (ADH) have been reproduced; the structural details of the ZnNS2O coordination in the complex and in DMSO-inhibited ADH are in reasonably good agreement.

引用

页码：1026 / 1027

页数：2

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