Meta-analysis of brain and cranial size in schizophrenia

被引:139
作者
Ward, KE
Friedman, L
Wise, A
Schulz, SC
机构
[1] CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,DEPT PSYCHIAT,CLEVELAND,OH 44106
[2] CASE WESTERN RESERVE UNIV,DEPT NEUROSCI,CLEVELAND,OH 44106
关键词
schizophrenia; meta-analysis; brain volume; intracranial volume; head size;
D O I
10.1016/S0920-9964(96)00076-X
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Several meta-analyses are presented that address the issue of brain and/or cranial size reductions in schizophrenia. Separate meta-analyses were conducted for brain size (n = 27 studies), intracranial size (n = 18) or extracranial size (n = 8). For each meta-analysis, the weighted composite effect size (d) was tested for statistical significance (the direction of the effect size was negative if patients with schizophrenia had smaller structure size than controls). The influence of several potential modifiers of effect size (age, methods, region, gender) was individually evaluated. The composite effect sizes for studies of brain, intracranial and extracranial measures were d = -0.26, (p<0.0001), d = -0.18, (p = 0.0012), and d = +0.14, (p = 0.16), respectively. Thus, the review found evidence for a small, but statistically significant reduction in brain and intracranial size in schizophrenia, but no evidence for a reduction in extracranial size. Studies based on axial image slices had significantly larger effects (d= -0.60) than the studies based on sagittal images (d= -0.09)(chi(2) = 14.0, p = 0.0002). In summary, the findings clearly support a small yet highly significant reduction of brain and intracranial size in schizophrenia.
引用
收藏
页码:197 / 213
页数:17
相关论文
共 113 条
  • [1] THICKENING OF SKULL IN SURGICALLY TREATED HYDROCEPHALUS
    ANDERSON, R
    KIEFFER, SA
    WOLFSON, JJ
    LONG, D
    PETERSON, HO
    [J]. AMERICAN JOURNAL OF ROENTGENOLOGY RADIUM THERAPY AND NUCLEAR MEDICINE, 1970, 110 (01): : 96 - &
  • [2] ANDREASEN N, 1986, ARCH GEN PSYCHIAT, V43, P136
  • [3] ANDREASEN NC, 1987, ARCH GEN PSYCHIAT, V44, P674
  • [4] THALAMIC ABNORMALITIES IN SCHIZOPHRENIA VISUALIZED THROUGH MAGNETIC-RESONANCE IMAGE AVERAGING
    ANDREASEN, NC
    ARNDT, S
    SWAYZE, V
    CIZADLO, T
    FLAUM, M
    OLEARY, D
    EHRHARDT, JC
    YUH, WTC
    [J]. SCIENCE, 1994, 266 (5183) : 294 - 298
  • [5] REGIONAL BRAIN ABNORMALITIES IN SCHIZOPHRENIA MEASURED WITH MAGNETIC-RESONANCE-IMAGING
    ANDREASEN, NC
    FLASHMAN, L
    FLAUM, M
    ARNDT, S
    SWAYZE, V
    OLEARY, DS
    EHRHARDT, JC
    YUH, WTC
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 272 (22): : 1763 - 1769
  • [6] ANDREASEN NC, 1990, ARCH GEN PSYCHIAT, V47, P35
  • [7] [Anonymous], 1989, DSTAT: Software for the meta-analytic review of research literatures
  • [8] AYLWARD EH, 1994, AM J PSYCHIAT, V151, P1448
  • [9] BARTA PE, 1990, AM J PSYCHIAT, V147, P1457
  • [10] Betz Barbara J., 1942, HUMAN BIOL, V14, P21