Up-regulation of E2F-1 in Down's syndrome brain exhibiting neuropathological features of Alzheimer-type dementia

被引：22

作者：

Motonaga, K

Itoh, M

Hirayama, A

Hirano, S

Becker, LE

Goto, Y

Takashima, S

机构：

[1] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Retardat & Birth Defect Res, Tokyo 1878502, Japan

[2] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Clin Lab, Tokyo 1878502, Japan

[3] Nakagawanosato Hosp Disabled Children, Matsubushi, Saitama, Japan

[4] Hosp Sick Children, Div Neuropathol, Toronto, ON M5G 1X8, Canada

来源：

BRAIN RESEARCH | 2001年 / 905卷 / 1-2期

关键词：

Down's syndrome; E2F-1; p53; Alzheimer's disease; amyloid beta protein; apoptosis;

D O I：

10.1016/S0006-8993(01)02535-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the expression of the apoptosis-related protein. E2F-1, in Down's syndrome (DS) brains. The immunoreactivity for E2F-1 was detected in the pyramidal neurons of the cerebral cortex from DS brains exhibiting the neuropathological features of dementia of Alzheimer type (DAT). in accordance with the amyloid beta protein (A beta) deposition in the neuron. Therefore. the implication is that A beta deposition may trigger E2F-1-mediated neuronal apoptosis in DS brains with DAT. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：250 / 253

页数：4

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