Effective accumulation of polyion complex micelle to experimental choroidal neovascularization in rats

被引：37

作者：

Ideta, R

Yanagi, Y

Tamaki, Y

Tasaka, F

Harada, A

Kataoka, K

机构：

[1] Univ Tokyo, Sch Med, Dept Ophthalmol, Bunkyo Ku, Tokyo 1138655, Japan

[2] Santen Pharmaceut Co Ltd, Div Res & Dev, Nara 6300101, Japan

[3] Osaka Prefecture Univ, Grad Sch Engn, Dept Appl Mat Sci, Sakai, Osaka 5998531, Japan

[4] Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan

来源：

FEBS LETTERS | 2004年 / 557卷 / 1-3期

关键词：

age-related macular degeneration; choroidal neovascularization; drug delivery system; nanotechnotogy; polyion complex micelle;

D O I：

10.1016/S0014-5793(03)01315-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exudative age-related macular degeneration, characterized by choroidal neovascularization (CNV), is a major cause of visual loss. In this study, we examined the distribution of the polyion complex (PIC) micelle encapsulating FITC-P(Lys) in blood and in experimental CNV in rats to investigate whether PIC micelle can be used for treatment of CNV. We demonstrate that PIC micelle has long-circulating characteristics, accumulating to the CNV lesions and is retained in the lesion for as long as 168 h after intravenous administration. These results raise the possibility that PIC micelles can be used for achieving effective drug targeting to CNV. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：21 / 25

页数：5

共 22 条

[1] AGE-RELATED MACULAR DEGENERATION [J].