Neurogenesis directed by Sirt1

被引：44

作者：

Libert, Sergiy ^{[1
]}

Cohen, Dena ^{[1
]}

Guarente, Leonard ^{[1
]}

机构：

[1] MIT, Cambridge, MA 02139 USA

来源：

NATURE CELL BIOLOGY | 2008年 / 10卷 / 04期

关键词：

D O I：

10.1038/ncb0408-373

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

differentiation of neuronal stem cells into astrocytes or neurons is important in maintaining brain function. Oxidative stress and inflammation are now shown to bias differentiation toward astrocytes by modulating activity of the anti-ageing gene Sirt1. These findings link a longevity gene to the activity of neuronal stem cells and their response to stress.

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收藏

页码：373 / 374

页数：2

相关论文

共 9 条

[1] Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration [J].

Araki, T ;

Sasaki, Y ;

Milbrandt, J .

SCIENCE, 2004, 305 (5686) :1010-1013

[2] Two neurons mediate diet-restriction-induced longevity in C-elegans [J].

Bishop, Nicholas A. ;

Guarente, Leonard .

NATURE, 2007, 447 (7144) :545-+

[3] SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis [J].

Kim, Dohoon ;

Nguyen, Minh Dang ;

Dobbin, Matthew M. ;

Fischer, Andre ;

Sananbenesi, Farahnaz ;

Rodgers, Joseph T. ;

Delalle, Ivana ;

Baur, Joseph A. ;

Sui, Guangchao ;

Armour, Sean M. ;

Puigserver, Pere ;

Sinclair, David A. ;

Tsai, Li-Huei .

EMBO JOURNAL, 2007, 26 (13) :3169-3179

[4] SIRT1 deacetylates and positively regulates the nuclear receptor LXR [J].

Li, Xiaoling ;

Zhang, Songwen ;

Blander, Gil ;

Tse, Jeanette G. ;

Krieger, Monty ;

Guarente, Leonard .

MOLECULAR CELL, 2007, 28 (01) :91-106

[5] Regulation of Drosophila life span by olfaction and food-derived odors [J].

Libert, Sergiy ;

Zwiener, Jessica ;

Chu, Xiaowen ;

VanVoorhies, Wayne ;

Roman, Gregg ;

Pletcher, Scott D. .

SCIENCE, 2007, 315 (5815) :1133-1137

[6] Negative control of p53 by Sir2α promotes cell survival under stress [J].

Luo, JY ;

Nikolaev, AY ;

Imai, S ;

Chen, DL ;

Su, F ;

Shiloh, A ;

Guarente, L ;

Gu, W .

CELL, 2001, 107 (02) :137-148

[7] SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α [J].

Nemoto, S ;

Fergusson, MM ;

Finkel, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (16) :16456-16460

[8]

PROZOROVSKI, 2008, NATURE CELL BIOL, V10, P385

[9] Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction [J].

Qin, Weiping ;

Yang, Tianle ;

Ho, Lap ;

Zhao, Zhong ;

Wang, Jun ;

Chen, Linghong ;

Zhao, Wei ;

Thiyagarajan, Meenakshisundaram ;

MacGrogan, Donal ;

Rodgers, Joseph T. ;

Puigserver, Pere ;

Sadoshima, Junichi ;

Deng, Haiteng ;

Pedrini, Steven ;

Gandy, Samuel ;

Sauve, Anthony A. ;

Pasinetti, Giulio M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (31) :21745-21754