Nitric oxide mediates anti-inflammatory action of extracorporeal shock waves

被引：192

作者：

Ciampa, AR

de Prati, AC

Amelio, E

Cavalieri, E

Persichini, T

Colasanti, M

Musci, G

Marlinghaus, E

Suzuki, H

Mariotto, S

机构：

[1] Univ Verona, Dipartimento Sci Neurol & Vis, Sez Chim Biol, I-37134 Verona, Italy

[2] Univ Verona, Unita Operat Chirurg Mano, Serv Terapia Onde Urto, Policlin GB Rossi,Azienda Osped Verona, I-37134 Verona, Italy

[3] Univ Roma Tre, Dipartimento Biol, Rome, Italy

[4] Univ Messina, Dipartimento Sci Microbiol Genet & Mol, Messina, Italy

[5] Storz Med AG, Appl Res Ctr, Kreuzlingen, Switzerland

来源：

FEBS LETTERS | 2005年 / 579卷 / 30期

关键词：

extracorporeal shock waves; inducible nitric oxide synthase; inflammation; NF-kappa B; nitric oxide;

D O I：

10.1016/j.febslet.2005.11.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here, we show that extracorporeal shock waves (ESW), at a low energy density value, quickly increase neuronal nitric oxide synthase (nNOS) activity and basal nitric oxide (NO) production in the rat glioma cell line C6. In addition, the treatment of C6 cells with ESW reverts the decrease of nNOS activity and NO production induced by a mixture of lipopolysaccharides (LPS), interferon-gamma (IFN-gamma) plus tumour necrosis factor-alpha (TNF-alpha). Finally, ESW treatment efficiently downregulates NF-kappa B activation and NF-kappa B-dependent gene expression, including inducible NOS and TNF-alpha. The present report suggests a possible molecular mechanism of the anti-inflammatory action of ESW treatment. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：6839 / 6845

页数：7

共 27 条

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