Enantioselective synthesis of α,α-disubstituted amines from nitroalkenes

被引：23

作者：

Leroux, ML ^{[1
]}

Le Gall, T ^{[1
]}

Mioskowski, C ^{[1
]}

机构：

[1] CEA Saclay, Serv Mol Marquees, F-91191 Gif Sur Yvette, France

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 13期

关键词：

D O I：

10.1016/S0957-4166(01)00323-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Disubstituted nitroalkenes were converted into enantiomerically enriched amines (isolated as their hydrochloride salts) with enantiomeric excesses of 88 to > 95% in three steps: (a) highly stereoselective conjugate addition of the potassium salt of 4-phenyloxazolidin-2-one; (b) radical-mediated removal of the nitro group: (c) cleavage of the oxazolidinone. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1817 / 1823

页数：7

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