Mespo:: a novel basic helix-loop-helix gene expressed in the presomitic mesoderm and posterior tailbud of Xenopus embryos

被引：29

作者：

Joseph, EM ^{[1
]}

Cassetta, LA ^{[1
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

来源：

MECHANISMS OF DEVELOPMENT | 1999年 / 82卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

basic helix-loop-helix transcription factor; paraxial mesoderm; segmentation; Xenopus laevis;

D O I：

10.1016/S0925-4773(99)00010-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have isolated a novel gene from Xenopus, called Mespo, which encodes a protein containing a basic helix-loop-helix (bHLH) motif characteristic of a family of transcriptional activators. Mespo expression begins at the gastrula stage and continues throughout tailbud stages; expression occurs in the presomitic mesoderm and the posterior tailbud. Mespo has high similarity to a subfamily of bHLH transcription factors involved in segmentation of the presomitic paraxial mesoderm. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：191 / 194

页数：4

共 20 条

[1]

BASSEZ T, 1990, DEVELOPMENT, V110, P955

[2] cMeso-1, a novel bHLH transcription factor, is involved in somite formation in chicken embryos [J].

Buchberger, A ;

Seidl, K ;

Klein, C ;

Eberhardt, H ;

Arnold, HH .

DEVELOPMENTAL BIOLOGY, 1998, 199 (02) :201-215

[3] Suppression subtractive hybridization: A method for generating differentially regulated or tissue-specific cDNA probes and libraries [J].

Diatchenko, L ;

Lau, YFC ;

Campbell, AP ;

Chenchik, A ;

Moqadam, F ;

Huang, B ;

Lukyanov, S ;

Lukyanov, K ;

Gurskaya, N ;

Sverdlov, ED ;

Siebert, PD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) :6025-6030

[4]

HAMILTON L, 1969, J EMBRYOL EXP MORPH, V22, P253

[5]

HARLAND RM, 1991, METHOD CELL BIOL, V36, P675

[6] A XENOPUS MESSENGER-RNA RELATED TO DROSOPHILA TWIST IS EXPRESSED IN RESPONSE TO INDUCTION IN THE MESODERM AND THE NEURAL CREST [J].

HOPWOOD, ND ;

PLUCK, A ;

GURDON, JB .

CELL, 1989, 59 (05) :893-903

[7] MYOD EXPRESSION IN THE FORMING SOMITES IS AN EARLY RESPONSE TO MESODERM INDUCTION IN XENOPUS-EMBRYOS [J].

HOPWOOD, ND ;

PLUCK, A ;

GURDON, JB .

EMBO JOURNAL, 1989, 8 (11) :3409-3417

[8]

JACOBSON AG, 1988, DEVELOPMENT, V104, P209

[9]

Jen WC, 1997, DEVELOPMENT, V124, P1169

[10]

MEIRER S, 1979, DEV BIOL, V73, P25

← 1 2 →