Chemokines and disease

被引：1174

作者：

Gerard, C ^{[1
]}

Rollins, BJ

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Dept Pediat, Boston, MA 02115 USA

[2] Harvard Univ, Dana Farber Canc Inst, Sch Med, Dept Adult Oncol, Boston, MA 02115 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

NATURE IMMUNOLOGY | 2001年 / 2卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/84209

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

We examine here several diseases that are associated with inappropriate activation of the chemokine network. Detailed comment has been restricted to pathological states for which there are compelling data either from clinical observations or animal models. These include cardiovascular disease, allergic inflammatory disease, transplantation, neuroinflammation, cancer and HIV-associated disease. Discussion focuses on therapeutic directions in which the rapidly evolving chemokine field appears to be headed.

引用

页码：108 / 115

页数：8

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