Identification of antioxidant and ACE-inhibitory peptides in fermented milk

被引：206

作者：

Hernández-Ledesma, B ^{[1
]}

Miralles, B ^{[1
]}

Amigo, L ^{[1
]}

Ramos, M ^{[1
]}

Recio, I ^{[1
]}

机构：

[1] CSIC, Inst Fermentac Ind, E-28006 Madrid, Spain

来源：

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE | 2005年 / 85卷 / 06期

关键词：

ACE-inhibitory peptides; antioxidant peptides; fermented milk; tandem mass spectrometry;

D O I：

10.1002/jsfa.2063

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The angiotensin-converting enzyme (ACE)-inhibitory activity and antioxidant properties of a commercial fermented milk from Europe were evaluated. This dairy product showed moderate ACE-inhibitory activity and ABTS(center dot+) radical-scavenging capacity. The peptides from most active fractions collected by reverse phase high-performance liquid chromatography (RP-HPLC) were sequenced by RP-HPLC-tandem mass spectrometry. This technique allowed rapid identification of peptides included in the most active fractions, and various potentially active peptides were recognised according to previous studies of structure-activity relationship. Three of the identified sequences had previously been described as potent ACE inhibitors. The structure of some sequences substantiated the presence of peptides with ACE-inhibitory, antioxidant and immunomodulatory activities. (c) 2005 Society of Chemical Industry.

引用

页码：1041 / 1048

页数：8

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