The Lac repressor: a second generation of structural and functional studies

被引：61

作者：

Bell, CE

Lewis, M

机构：

[1] Univ Penn, Sch Med, Johnson Fdn, Philadelphia, PA 19102 USA

[2] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19102 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2001年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-440X(00)00180-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the past year, the crystal structure of a dimeric version of the Escherichia coli Lac repressor bound to operator DNA was determined at 2.6 Angstrom resolution, providing a closer View of the operator-bound conformation of the repressor. Refined NMR studies of the DNA-binding portion of the repressor complexed to operator DNA have revealed further details of the unique DNA-binding interactions of the repressor. The structural studies have been complemented by continued biochemical studies, with the overall goal of understanding the mechanism of allosteric regulation.

引用

页码：19 / 25

页数：7

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