Cholesteryl ester transfer protein (CETP) I405V polyrnorphism and longevity in Italian centenarians

被引：49

作者：

Cellini, E

Nacmias, B

Olivieri, F

Ortenzi, L

Tedde, A

Bagnoli, S

Petruzzi, C

Franceschi, C

Sorbi, S

机构：

[1] Univ Florence, Dept neurol & Psychiat Sci, I-50134 Florence, Italy

[2] INRCA, Dept Gerontol Res, Ancona, Italy

[3] Assoc L Petruzzi, Casa Cura Villa Serena, Pescara, Italy

[4] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

[5] Univ Bologna, Intderdept Ctr L Galvani, Bologna, Italy

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2005年 / 126卷 / 6-7期

关键词：

longevity; healthy aging; polymorphisms; cholesteryl ester transfer protein gene; genetic heterogeneity;

D O I：

10.1016/j.mad.2005.01.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

A common polymorphism (I405V) in exon 14 of the cholesteryl ester transfer protein (CETP) gene has been recently associated to healthy aging in Ashkenazi Jewish. In order to study this genetic effect in long-lived individuals with a different ethnicity, we analyzed the allele and genotype distributions of the CETP polymorphism a sample of Italian centenarians. Our result does not confirm the association between the I405V CETP variation and the healthy aging phenotype described in the Ashkenazi Jewish population and suggests that other gene environment interactions contribute to longevity. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：826 / 828

页数：3

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