The roles of cadherins and nectins in interneuronal synapse formation

被引:60
作者
Takai, Y
Shimizu, K
Ohtsuka, T
机构
[1] Osaka Univ, Grad Sch Med, Fac Med, Dept Mol Biol & Biochem, Suita, Osaka 5650871, Japan
[2] KAN Res Inst, Kyoto 6008815, Japan
关键词
D O I
10.1016/j.conb.2003.09.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cadherins are Ca2+-dependent intercellular adhesion molecules (CAMs) and they play key roles in the intercellular junctions of a wide variety of cells, including interneuronal synapses. Nectins are Ca2+-independent immunoglobulin-like CAMs and they are also involved in the organization of various types of intercellular junctions, including interneuronal synapses, either in cooperation with or independently of cadherins. Intercellular adhesion through nectins induces activation of Cdc42 and Rac small G proteins, leading to a reorganization of the actin cytoskeleton, gene expression, and cell polarization.
引用
收藏
页码:520 / 526
页数:7
相关论文
共 41 条
[1]   DEVELOPMENT OF THE MOSSY FIBERS OF THE DENTATE GYRUS .1. A LIGHT AND ELECTRON-MICROSCOPIC STUDY OF THE MOSSY FIBERS AND THEIR EXPANSIONS [J].
AMARAL, DG ;
DENT, JA .
JOURNAL OF COMPARATIVE NEUROLOGY, 1981, 195 (01) :51-86
[2]   SynCAM, a synaptic adhesion molecule that drives synapse assembly [J].
Biederer, T ;
Sara, Y ;
Mozhayeva, M ;
Atasoy, D ;
Liu, XR ;
Kavalali, ET ;
Südhof, TC .
SCIENCE, 2002, 297 (5586) :1525-1531
[3]   SYNAPTIC STRUCTURE AND FUNCTION - DYNAMIC ORGANIZATION YIELDS ARCHITECTURAL PRECISION [J].
BURNS, ME ;
AUGUSTINE, GJ .
CELL, 1995, 83 (02) :187-194
[4]   Neurexin mediates the assembly of presynaptic terminals [J].
Dean, C ;
Scholl, FG ;
Choih, J ;
DeMaria, S ;
Berger, J ;
Isacoff, E ;
Scheiffele, P .
NATURE NEUROSCIENCE, 2003, 6 (07) :708-716
[5]   The presynaptic cytomatrix of brain synapses [J].
Dresbach, T ;
Qualmann, B ;
Kessels, MM ;
Garner, CC ;
Gundelfinger, ED .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2001, 58 (01) :94-116
[6]   A model for central synaptic junctional complex formation based on the differential adhesive specificities of the cadherins [J].
Fannon, AM ;
Colman, DR .
NEURON, 1996, 17 (03) :423-434
[7]   Regulation of cadherin adhesive activity [J].
Gumbiner, BM .
JOURNAL OF CELL BIOLOGY, 2000, 148 (03) :399-403
[8]   Cell adhesion: The molecular basis of tissue architecture and morphogenesis [J].
Gumbiner, BM .
CELL, 1996, 84 (03) :345-357
[9]   Cdc42 and Rac small G proteins activated by trans- interactions of nectins are involved in activation of c-Jun N-terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts [J].
Honda, T ;
Shimizu, K ;
Kawakatsu, T ;
Fukuhara, A ;
Irie, K ;
Nakamura, T ;
Matsuda, M ;
Takai, Y .
GENES TO CELLS, 2003, 8 (05) :481-491
[10]   Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus [J].
Inagaki, M ;
Irie, K ;
Deguchi-Tawarada, M ;
Ikeda, W ;
Ohtsuka, T ;
Takeuchi, M ;
Takai, Y .
JOURNAL OF COMPARATIVE NEUROLOGY, 2003, 460 (04) :514-524