The roles of cadherins and nectins in interneuronal synapse formation

被引：60

作者：

Takai, Y

Shimizu, K

Ohtsuka, T

机构：

[1] Osaka Univ, Grad Sch Med, Fac Med, Dept Mol Biol & Biochem, Suita, Osaka 5650871, Japan

[2] KAN Res Inst, Kyoto 6008815, Japan

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2003年 / 13卷 / 05期

关键词：

D O I：

10.1016/j.conb.2003.09.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cadherins are Ca2+-dependent intercellular adhesion molecules (CAMs) and they play key roles in the intercellular junctions of a wide variety of cells, including interneuronal synapses. Nectins are Ca2+-independent immunoglobulin-like CAMs and they are also involved in the organization of various types of intercellular junctions, including interneuronal synapses, either in cooperation with or independently of cadherins. Intercellular adhesion through nectins induces activation of Cdc42 and Rac small G proteins, leading to a reorganization of the actin cytoskeleton, gene expression, and cell polarization.

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页码：520 / 526

页数：7

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