Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis

被引：539

作者：

Molnar, Vilim ^{[1
,2
,3
]}

Matisic, Vid ^{[1
,2
]}

Kodvanj, Ivan ^{[4
]}

Bjelica, Roko ^{[1
,2
]}

Jelec, Zeljko ^{[1
,2
,5
]}

Hudetz, Damir ^{[1
,2
,3
,6
]}

Rod, Eduard ^{[1
,2
]}

Cukelj, Fabijan ^{[1
,2
,7
,8
,9
]}

Vrdoljak, Trpimir ^{[1
,2
,6
]}

Vidovic, Dinko ^{[1
,2
,7
]}

Staresinic, Mario ^{[10
]}

Sabalic, Srecko ^{[7
]}

Dobricic, Borut ^{[1
,2
,11
]}

Petrovic, Tadija ^{[1
,2
,8
]}

Anticevic, Darko ^{[1
,2
,12
]}

Boric, Igor ^{[1
,2
,9
,10
,13
,14
]}

Kosir, Rok ^{[15
]}

Zmrzljak, Ursula Prosenc ^{[15
]}

Primorac, Dragan ^{[1
,2
,3
,10
,12
,13
,14
,16
,17
,18
]}

机构：

[1] St Catherine Specialty Hosp, Zabok 49210, Croatia

[2] St Catherine Specialty Hosp, Zagreb 10000, Croatia

[3] Josip Juraj Strossmayer Univ Osijek, Fac Med, Osijek 31000, Croatia

[4] Univ Zagreb, Sch Med, Dept Pharmacol, Zagreb 10000, Croatia

[5] Univ North, Dept Nursing, Varazhdin 48000, Croatia

[6] Clin Hosp Sveti Duh, Dept Orthopaed Surg, Zagreb 10000, Croatia

[7] Univ Hosp Sisters Mercy, Clin Traumatol, Draskoviceva 19, Zagreb 10000, Croatia

[8] Univ Split, Dept Hlth Studies, Split 21000, Croatia

[9] Med Univ Merkur Hosp, Dept Traumatol, Zagreb 10000, Croatia

[10] Univ Split, Med Sch, Split 21000, Croatia

[11] Univ Hosp Dubrava, Dept Orthopaed & Traumatol, Zagreb 10000, Croatia

[12] Josip Juraj Strossmayer Univ Osijek, Fac Dent Med & Hlth, Osijek 31000, Croatia

[13] Univ Mostar, Med Sch, Mostar 88000, Bosnia & Herceg

[14] Univ Rijeka, Med Sch, Rijeka 51000, Croatia

[15] Labena Ltd, BIA Separat CRO, Mol Biol Lab, Ljubljana 1000, Slovenia

[16] Med Sch REGIOMED, D-96450 Coburg, Germany

[17] Penn State Univ, Eberly Coll Sci, University Pk, PA 16802 USA

[18] Univ New Haven, Henry C Lee Coll Criminal Justice & Forens Sci, West Haven, CT 06516 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 17期

关键词：

osteoarthritis; cytokines; chemokines; pathogenesis; inflammation; biomarker; TUMOR-NECROSIS-FACTOR; SOLUBLE INTERLEUKIN-6 RECEPTOR; FIBROBLAST-LIKE SYNOVIOCYTES; HUMAN ARTICULAR CHONDROCYTES; NATURAL-KILLER-CELLS; SYNOVIAL-FLUID; KNEE OSTEOARTHRITIS; RHEUMATOID-ARTHRITIS; FACTOR-ALPHA; CARTILAGE LOSS;

D O I：

10.3390/ijms22179208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The pathogenesis of this degenerative process is not completely understood; however, a low-grade inflammation leading to an imbalance between anabolic and katabolic processes is a well-established factor. The complex network of cytokines regulating these processes and cell communication has a central role in the development and progression of osteoarthritis. Concentrations of both proinflammatory and anti-inflammatory cytokines were found to be altered depending on the osteoarthritis stage and activity. In this review, we analyzed individual cytokines involved in the immune processes with an emphasis on their function in osteoarthritis.

引用

页数：23

共 196 条

[1]

Abul K., 2021, CELL MOL IMMUNOL

[2]

Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases [J].

Akdis, Muebeccel ;

Burgler, Simone ;

Crameri, Reto ;

Eiwegger, Thomas ;

Fujita, Hiroyuki ;

Gomez, Enrique ;

Klunker, Sven ;

Meyer, Norbert ;

O'Mahony, Liam ;

Palomares, Oscar ;

Rhyner, Claudio ;

Quaked, Nadia ;

Schaffartzik, Anna ;

Van De Veen, Willem ;

Zeller, Sabine ;

Zimmermann, Maya ;

Akdis, Cezmi A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (03) :701-U317

[3]

Interleukin-15 in autoimmunity [J].

Allard-Chamard, Hugues ;

Mishra, Hemant K. ;

Nandi, Madhuparna ;

Mayhue, Marian ;

Menendez, Alfredo ;

Ilangumaran, Subburaj ;

Ramanathan, Sheela .

CYTOKINE, 2020, 136

[4]

Correlation between synovial fluid cytokine concentrations and limb function in normal dogs and in dogs with lameness from spontaneous osteoarthritis [J].

Allen, Philip I. ;

Conzemius, Michael G. ;

Evans, Richard B. ;

Kiefer, Kristina .

VETERINARY SURGERY, 2019, 48 (05) :770-779

[5]

Immune activation and inflammation in HIV-I infection: causes and consequences [J].

Appay, V. ;

Sauce, D. .

JOURNAL OF PATHOLOGY, 2008, 214 (02) :231-241

[6]

Increased Serum Levels of IL-17A and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis [J].

Askari, Alireza ;

Naghizadeh, Mohammad Mehdi ;

Homayounfar, Reza ;

Shahi, Abbas ;

Afsarian, Mohammad Hosein ;

Paknahad, Abbas ;

Kennedy, Derek ;

Ataollahi, Mohammad Reza .

PLOS ONE, 2016, 11 (11)

[7]

Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis [J].

Attur, M. ;

Statnikov, A. ;

Samuels, J. ;

Li, Z. ;

Alekseyenko, A. V. ;

Greenberg, J. D. ;

Krasnokutsky, S. ;

Rybak, L. ;

Lu, Q. A. ;

Todd, J. ;

Zhou, H. ;

Jordan, J. M. ;

Kraus, V. B. ;

Aliferis, C. F. ;

Abramson, S. B. .

OSTEOARTHRITIS AND CARTILAGE, 2015, 23 (11) :1915-1924

[8]

Correlation between systemic markers of inflammation and local synovitis in knee osteoarthritis [J].

Babaei, Mansour ;

Javadian, Yahya ;

Narimani, Hossein ;

Ranaei, Mohammad ;

Heidari, Behezad ;

Basereh, Hossein ;

Gholinia, Hemat ;

Firouzjahi, Alireza .

CASPIAN JOURNAL OF INTERNAL MEDICINE, 2019, 10 (04) :383-387

[9]

The balance of interleukin (IL)-6, IL-6•soluble IL-6 receptor (sIL-6R), and IL-6•sIL-6R•sgp130 complexes allows simultaneous classic and trans-signaling [J].

Baran, Paul ;

Hansen, Selina ;

Waetzig, Georg H. ;

Akbarzadeh, Mohammad ;

Lamertz, Larissa ;

Huber, Heinrich J. ;

Ahmadian, M. Reza ;

Moll, Jens M. ;

Scheller, Juergen .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (18) :6762-6775

[10]

Circulating IL-10 is compromised in patients predisposed to developing and in patients with severe knee osteoarthritis [J].

Barker, Tyler ;

Rogers, Victoria E. ;

Henriksen, Vanessa T. ;

Trawick, Roy H. ;

Momberger, Nathan G. ;

Lynn Rasmussen, G. .

SCIENTIFIC REPORTS, 2021, 11 (01)

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