Blood concentrations of tetracaine and its metabolite following spinal anesthesia

被引：12

作者：

Kudo, K

Hino, Y

Ikeda, N ^{[1
]}

Inoue, H

Takahashi, S

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Forens Pathol & Sci, Fukuoka 8128582, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Anesthesiol & Crit Care Med, Fukuoka 8128582, Japan

来源：

FORENSIC SCIENCE INTERNATIONAL | 2001年 / 116卷 / 01期

关键词：

forensic toxicology; spinal anesthesia; tetracaine; p-butylaminobenzoic acid; mepivacaine;

D O I：

10.1016/S0379-0738(00)00342-X

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Blood concentrations of tetracaine and its metabolite, p-butylaminobenzoic acid. were measured after spinal anesthesia with tetracaine which had been administered to patients under going orthopedic surgery. Tetracaine, an ester anesthetic, was given to 10 patients, the dose was 8-14 mg, and blood samples were collected 1, 2 and 6 h after the injection of tetracaine. We used gas chromatography/mass spectrometry for purposes of analysis. Tetracaine was not detected in any blood sample, but the metabolite was detected in each sample with the mean concentrations of 126.5, 97.9 and 43.3 ng/ml at 1, 7 and 6 h, respectively. This data will be useful in determination of the cause of death after spinal anesthesia with tetracaine, (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：9 / 14

页数：6

共 8 条

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[2]

FUKUI M, 1970, JPN J LEGAL MED, V24, P136

[3] Sensitive and selective determination of tetracaine and its metabolite in human samples by gas chromatography-mass spectrometry [J].