Microbiotal influence on T cell subset development

被引：71

作者：

Atarashi, Koji ^{[1
]}

Umesaki, Yoshinori ^{[2
]}

Honda, Kenya ^{[1
,3
]}

机构：

[1] Univ Tokyo, Dept Immunol, Grad Sch Med, Tokyo 1130033, Japan

[2] Yakult Cent Inst Microbiol Res, Tokyo 1868650, Japan

[3] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol PRESTO, Kawaguchi, Saitama 3320012, Japan

来源：

SEMINARS IN IMMUNOLOGY | 2011年 / 23卷 / 02期

关键词：

Microbial flora; Th17; Treg; Segmented filamentous bacteria; SEGMENTED FILAMENTOUS BACTERIA; ROR-GAMMA-T; INFLAMMATORY-BOWEL-DISEASE; GROWTH-FACTOR-BETA; TGF-BETA; IMMUNE-SYSTEM; RETINOIC-ACID; TH17; CELLS; INTESTINAL HOMEOSTASIS; IL-17-PRODUCING CELLS;

D O I：

10.1016/j.smim.2011.01.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The mammalian alimentary tract harbors hundreds of bacterial species that constitute the indigenous microbial flora. The indigenous microbial flora has long been appreciated for its role in host immune system development. Recent reports suggest that components of the microbial flora differentially affect the proportion and number of functionally distinct subsets of T cells in the intestine. Substantial changes in the composition of the microbiota are associated with inflammatory bowel disease. This review will discuss the importance of individual species of microbial flora in the induction of T cell subsets, particularly TM17 cells and regulatory T (Treg) cells in the intestine. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：146 / 153

页数：8

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