Entrainment of circadian rhythms by S-20098, a melatonin agonist, is dose and plasma concentration dependent

被引：89

作者：

Martinet, L ^{[1
]}

GuardiolaLemaitre, B ^{[1
]}

Mocaer, E ^{[1
]}

机构：

[1] INST RECH INT SERVIER, F-92415 COURBEVOIE, FRANCE

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1996年 / 54卷 / 04期

关键词：

circadian rhythm; entrainment; dose-response; S-20098; melatonin; ipsapirone; rat;

D O I：

10.1016/0091-3057(95)02221-X

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present study determined first the dose-response (0.5 to 10 mg . kg(-1)) to daily oral administration of S-20098. a melatonin agonist, in entraining circadian rhythms of rats free-running in constant darkness; second, the relation between entrainment and the plasma concentration of S-20098. Finally, responses to 8 mg . kg(-1) of S-20098 were compared with those obtained with the same dose of melatonin and ipsapirone. Responses were classified as negative, transient, or true entrainment. The data indicated a clear dose-dependent response from 2.5 to 10 mg . kg(-1) of S-20098 with an EDS, of 5.7 mg . kg(-1) for true entrainment and a clear relation between entrainment and the plasma concentration of S-20098. S-20098 was as effective as melatonin to entrain free-running rhythms. Ipsapirone was ineffective in our experimental conditions.

引用

页码：713 / 718

页数：6

共 22 条

[11] MELATONIN SHIFTS HUMAN CIRCADIAN-RHYTHMS ACCORDING TO A PHASE RESPONSE CURVE [J].