Non-ionic surfactant based vesicles (niosomes) in drug delivery

The self assembly of non-ionic surfactants into vesicles was first reported in the seventies by researchers in the cosmetic industry. Since then a number of groups world wide have studied non-ionic surfactant vesicles (niosomes) with a view to evaluating their potential as drug carriers. This article presents a summary of the achievements in the field to date. Niosomes may be formed form a diverse array of amphiphiles bearing sugar, polyoxyethylene, polyglycerol, crown ether and amino acid hydrophilic head groups and these amphiphiles typically possess one to two hydrophobic alkyl, perfluoroalkyl or steroidal groups. The self assembly of surfactants into niosomes is governed not only by the nature of the surfactant but by the presence of membrane additives, the nature of the drug encapsulated and the actual method of preparation. Methods of niosome preparation and the number of different morphologies that have been identified are detailed. The influence of formulation factors on niosome stability is also examined as are methods to optimise drug loading. In vivo these systems have been evaluated as immunological adjuvants, anti-cancer/anti-infective drug targeting agents and carriers of anti-inflammatory drugs. Niosomes have also been used in diagnostic imaging. Efforts to achieve transdermal and ophthalmic drug delivery with some formulations are also discussed. (C) 1998 Elsevier Science B.V. All rights reserved.