Discovery of N-[2-[5-[amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834):: A potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa

被引：73

作者：

Phillips, GB ^{[1
]}

Buckman, BO ^{[1
]}

Davey, DD ^{[1
]}

Eagen, KA ^{[1
]}

Guilford, WJ ^{[1
]}

Hinchman, J ^{[1
]}

Ho, E ^{[1
]}

Koovakkat, S ^{[1
]}

Liang, A ^{[1
]}

Light, DR ^{[1
]}

Mohan, R ^{[1
]}

Ng, HP ^{[1
]}

Post, JM ^{[1
]}

Shaw, KJ ^{[1
]}

Smith, D ^{[1
]}

Subramanyam, B ^{[1
]}

Sullivan, ME ^{[1
]}

Trinh, L ^{[1
]}

Vergona, R ^{[1
]}

Walters, J ^{[1
]}

White, K ^{[1
]}

Whitlow, M ^{[1
]}

Wu, S ^{[1
]}

Xu, W ^{[1
]}

Morrissey, MM ^{[1
]}

机构：

[1] Discovery Res, Berlex Biosci, Richmond, CA 94804 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 41卷 / 19期

关键词：

D O I：

10.1021/jm980280h

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：3557 / 3562

页数：6

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