Cord blood transplantation in children with haematological malignancies

被引：12

作者：

Bertaina, Alice ^{[2
]}

Bernardo, Maria Ester

Caniglia, Maurizio

Vinti, Luciana

Giorgiani, Giovanna ^{[2
]}

Locatelli, Franco ^{[1
,2
]}

机构：

[1] Univ Pavia, IRCCS Osped Bambino Gesu, Dept Paediat Haematol Oncol, I-00165 Rome, Italy

[2] Univ Pavia, Dept Pediat, I-00165 Rome, Italy

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2010年 / 23卷 / 02期

关键词：

umbilical cord blood transplantation; childhood acute leukemia; double cord transplantation; cell dose; leukemia recurrence; intrabone cord blood transplantation; VERSUS-HOST-DISEASE; HEMATOPOIETIC STEM-CELLS; DONOR BONE-MARROW; UNRELATED DONORS; ACUTE-LEUKEMIA; PEDIATRIC-PATIENTS; NONMALIGNANT DISEASE; PLACENTAL-BLOOD; SIBLING DONOR; OUTCOMES;

D O I：

10.1016/j.beha.2010.06.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Umbilical cord blood transplantation (UCBT) is largely used to treat children affected by haematological malignant disorders. In comparison to bone marrow transplantation (BMT), advantages of UCBT include lower incidence and severity of graft-versus-host disease, easier procurement and prompter availability of cord blood cells, and the possibility of using donors having HLA disparities with the recipient. The large experience accumulated so far has shown that UCBT offers to children a probability of cure at least comparable to that of patients transplanted with bone marrow cells. Since it has been demonstrated that an inverse correlation between the number of nucleated cord blood cells infused per kg recipient body weight and the risk of dying for transplantation-related causes exists, recently developed strategies aimed at increasing the number of cord blood progenitors and at favouring stem cell homing could further optimize the outcome of children with leukemia or other malignancies receiving UCBT. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：189 / 196

页数：8

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