Intrinsic biophysical diversity decorrelates neuronal firing while increasing information content

被引:219
作者
Padmanabhan, Krishnan [1 ,2 ]
Urban, Nathaniel N. [1 ,2 ,3 ]
机构
[1] Carnegie Mellon Univ, Dept Biol Sci, Pittsburgh, PA 15213 USA
[2] Ctr Neural Basis Cognit, Pittsburgh, PA USA
[3] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA USA
关键词
RAT OLFACTORY-BULB; PYRAMIDAL NEURONS; NEOCORTICAL NEURONS; MITRAL/TUFTED CELLS; ODOR DISCRIMINATION; LATERAL INHIBITION; ANTENNAL LOBE; SENSORY INPUT; RELIABILITY; CIRCUIT;
D O I
10.1038/nn.2630
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Although examples of variation and diversity exist throughout the nervous system, their importance remains a source of debate. Even neurons of the same molecular type have notable intrinsic differences. Largely unknown, however, is the degree to which these differences impair or assist neural coding. We examined the outputs from a single type of neuron, the mitral cells of the mouse olfactory bulb, to identical stimuli and found that each cell's spiking response was dictated by its unique biophysical fingerprint. Using this intrinsic heterogeneity, diverse populations were able to code for twofold more information than their homogeneous counterparts. In addition, biophysical variability alone reduced pair-wise output spike correlations to low levels. Our results indicate that intrinsic neuronal diversity is important for neural coding and is not simply the result of biological imprecision.
引用
收藏
页码:1276 / 1282
页数:7
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