Short Report: Seroreactivity to a Large Panel of Field-Derived Plasmodium falciparum Apical Membrane Antigen 1 and Merozoite Surface Protein 1 Variants Reflects Seasonal and Lifetime Acquired Responses to Malaria

被引：20

作者：

Bailey, Jason A. ^{[2
]}

Pablo, Jozelyn ^{[3
]}

Niangaly, Amadou ^{[4
,5
]}

Travassos, Mark A. ^{[2
]}

Ouattara, Amed ^{[2
]}

Coulibaly, Drissa ^{[4
,5
]}

Laurens, Matthew B. ^{[2
]}

Takala-Harrison, Shannon L. ^{[2
]}

Lyke, Kirsten E. ^{[2
]}

Skinner, Jeff ^{[6
]}

Berry, Andrea A.

Jasinskas, Algis ^{[3
]}

Nakajima-Sasaki, Rie ^{[3
]}

Kouriba, Bourema ^{[7
]}

Thera, Mahamadou A. ^{[4
,5
]}

Felgner, Philip L. ^{[3
]}

Doumbo, Ogobara K. ^{[7
]}

Plowe, Christopher V. ^{[1
,2
]}

机构：

[1] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA

[3] Univ Calif Irvine, Div Infect Dis, Irvine, CA USA

[4] Univ Bamako, Fac Med, Malaria Res & Training Ctr Bamako, Bamako, Mali

[5] Mali Univ Sci Tech & Technol Bamako, Malaria Res & Training Ctr, Bamako, Mali

[6] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA

[7] Univ Sci Tech & Technol Bamako, Malaria Res & Training Ctr, Bamako, Mali

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2015年 / 92卷 / 01期

关键词：

ALLELE-SPECIFIC EFFICACY; MALIAN ADULTS; VACCINE; IMMUNOGENICITY; INFECTION; CHILDREN; SAFETY; TRIAL;

D O I：

10.4269/ajtmh.14-0140

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

Parasite antigen diversity poses an obstacle to developing an effective malaria vaccine. A protein microarray containing Plasmodium falciparum apical membrane antigen 1 (AMA1, n = 57) and merozoite surface protein 1 19-kD (MSP1(19), n = 10) variants prevalent at a malaria vaccine testing site in Bandiagara, Mali, was used to assess changes in seroreactivity caused by seasonal and lifetime exposure to malaria. Malian adults had significantly higher magnitude and breadth of seroreactivity to variants of both antigens than did Malian children. Seroreactivity increased over the course of the malaria season in children and adults, but the difference was more dramatic in children. These results help to validate diversity-covering protein microarrays as a promising tool for measuring the breadth of antibody responses to highly variant proteins, and demonstrate the potential of this new tool to help guide the development of malaria vaccines with strain-transcending efficacy.

引用

页码：9 / 12

页数：4

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