The identification of salicylates as normal constituents of serum: a link between diet and health?

被引：36

作者：

Paterson, JR

Blacklock, C

Campbell, G

Wiles, D

Lawrence, JR

机构：

[1] Dumfries & Galloway Royal Infirm, Area Dept Biochem, Dumfries DG1 4AP, Scotland

[2] Dumfries & Galloway Royal Infirm, Dept Med, Dumfries DG1 4AP, Scotland

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1998年 / 51卷 / 07期

关键词：

salicylic acid; 2,3- and 2,5-dihydroxybenzoic acids; normal serum constituents; diet;

D O I：

10.1136/jcp.51.7.502

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Aim-To examine sera for the presence of salicylic acid and 2,3- and 2,5-dihydroxybenzoic acids (2,3- and 2,5-DHBA), in individuals not taking salicylate drugs. Methods-Extracts of acidified serum samples were analysed by high performance liquid chromatography with electrochemical detection. The chromatographic conditions were altered, and the retention times of the unknown compounds compared against authentic salicylic acid, 2,3-DHBA, and 2,5-DHBA. Serum samples (some spiked with salicylic acid) were incubated with salicylate hydroxylase and analyses undertaken. An extract of acidified serum was derivatised using N-methyl-N-trimethylsilyltrifluoroacetamide and the salicylic acid derivative identified by gas chromatography-mass spectrometry. Results-Salicylic acid, 2,3-DHBA, and 2,5-DHBA were identified as being normal constituents of serum. Conclusions-Salicylic acid, 2,3-DHBA, and 2,5-DHBA possess anti-inflammatory properties. The finding that these compounds are present as normal constituents of serum, possibly arising from diet, raises important questions as to their role in the promotion of health.

引用

页码：502 / 505

页数：4

共 22 条

[1] COLLABORATIVE OVERVIEW OF RANDOMIZED TRIALS OF ANTIPLATELET THERAPY .1. PREVENTION OF DEATH, MYOCARDIAL-INFARCTION, AND STROKE BY PROLONGED ANTIPLATELET THERAPY IN VARIOUS CATEGORIES OF PATIENTS [J].

ALTMAN, R ;

CARRERAS, L ;

DIAZ, R ;

FIGUEROA, E ;

PAOLASSO, E ;

PARODI, JC ;

CADE, JF ;

DONNAN, G ;

EADIE, MJ ;

GAVAGHAN, TP ;

OSULLIVAN, EF ;

PARKIN, D ;

RENNY, JTG ;

SILAGY, C ;

VINAZZER, H ;

ZEKERT, F ;

ADRIAENSEN, H ;

BERTRANDHARDY, JM ;

BRAN, M ;

DAVID, JL ;

DRICOT, J ;

LAVENNEPARDONGE, E ;

LIMET, R ;

LOWENTHAL, A ;

MORIAU, M ;

SCHAPIRA, S ;

SMETS, P ;

SYMOENS, J ;

VERHAEGHE, R ;

VERSTRAETE, M ;

ATALLAH, A ;

BARNETT, H ;

BATISTA, R ;

BLAKELY, J ;

CAIRNS, JA ;

COTE, R ;

CROUCH, J ;

EVANS, G ;

FINDLAY, JM ;

GENT, M ;

LANGLOIS, Y ;

LECLERC, J ;

NORRIS, J ;

PINEO, GF ;

POWERS, PJ ;

ROBERTS, R ;

SCHWARTZ, L ;

SICURELLA, J ;

TAYLOR, W ;

THEROUX, P .

BMJ-BRITISH MEDICAL JOURNAL, 1994, 308 (6921) :81-100

[2] SOME CHARACTERISTICS OF PROSTAGLANDIN SYNTHESIZING SYSTEM IN RABBIT KIDNEY MICROSOMES [J].

BLACKWELL, GJ ;

FLOWER, RJ ;

VANE, JR .

BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 398 (01) :178-190

[3] Rapid high-performance liquid chromatographic assay for salicylic acid in plasma without solvent extraction [J].

Coudray, C ;

Mangournet, C ;

Bouhadjeb, S ;

Faure, H ;

Favier, A .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1996, 34 (04) :166-173

[4] SALICYLATE METABOLISM IN MAN [J].

DAVISON, C .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1971, 179 (JUL6) :249-+

[5]

Elder DJE, 1996, CANCER RES, V56, P2273

[6]

FAIRLEY P, 1978, CONQUEST PAIN, P124

[7]

FLOWER RJ, 1974, PHARMACOL RES COMMUN, V26, P33

[8] Antioxidant vitamins, cancer, and cardiovascular disease [J].

Greenberg, ER ;

Sporn, MB .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (18) :1189-1190

[9] 2,3-DIHYDROXYBENZOIC ACID IS A PRODUCT OF HUMAN ASPIRIN METABOLISM [J].

GROOTVELD, M ;

HALLIWELL, B .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (02) :271-280

[10] IS ASPIRIN A PRODRUG FOR ANTIOXIDANT AND CYTOKINE-MODULATING OXYMETABOLITES [J].

HAYNES, DR ;

WRIGHT, PFA ;

GADD, SJ ;

WHITEHOUSE, MW ;

VERNONROBERTS, B .

AGENTS AND ACTIONS, 1993, 39 (1-2) :49-58

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