A life course approach to chronic disease epidemiology

被引：618

作者：

Lynch, J ^{[1
]}

Smith, GD

机构：

[1] Univ Michigan, Dept Epidemiol, Ctr Social Epidemiol & Populat Hlth, Ann Arbor, MI 48104 USA

[2] Univ Bristol, Dept Social Med, Bristol BS8 2PR, Avon, England

来源：

ANNUAL REVIEW OF PUBLIC HEALTH | 2005年 / 26卷

关键词：

time; risk factor; population;

D O I：

10.1146/annurev.publhealth.26.021304.144505

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A life course approach to chronic disease epidemiology uses a multidisciplinary framework to understand the importance of time and timing in associations between exposures and outcomes at the individual and population levels. Such an approach to chronic diseases is enriched by specification of the particular way that time and timing in relation to physical growth, reproduction, infection, social mobility, and behavioral transitions, etc., influence various adult chronic diseases in different ways, and more ambitiously, by how these temporal processes are interconnected and manifested in population-level disease trends. In this review, we discuss some historical background to life course epidemiology and theoretical models of life course processes, and we review some of the empirical evidence linking life course processes to coronary heart disease, hemorrhagic stroke, type 11 diabetes, breast cancer, and chronic obstructive pulmonary disease. We also underscore that a life course approach offers a way to conceptualize how underlying socio-environmental determinants of health, experienced at different life course stages, can differentially influence the development of chronic diseases, as mediated through proximal specific biological processes.

引用

页码：1 / 35

页数：35

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