Synthesis and structure-activity relationships of guan analogues as phosphodiesterase 7 (PDE7) inhibitors

被引：45

作者：

Barnes, MJ ^{[1
]}

Cooper, N ^{[1
]}

Davenport, RJ ^{[1
]}

Dyke, HJ ^{[1
]}

Galleway, FP ^{[1
]}

Galvin, FCA ^{[1
]}

Gowers, L ^{[1
]}

Haughan, AF ^{[1
]}

Lowe, C ^{[1
]}

Meissner, JWG ^{[1
]}

Montana, JG ^{[1
]}

Morgan, T ^{[1
]}

Picken, CL ^{[1
]}

Watson, RJ ^{[1
]}

机构：

[1] Celltech R&D, Cambridge CB1 6GS, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)00125-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a novel series of guanine analogues is reported. The compounds have been assessed in vitro and some analogues have been found to be inhibitors of phosphodiesterase type 7 (PDE7). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1081 / 1083

页数：3

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