Innate immunity, insulin resistance and type 2 diabetes

被引：152

作者：

Fernandez-Real, Jose Manuel ^{[1
,2
]}

Pickup, John C. ^{[3
,4
]}

机构：

[1] Univ Hosp Girona Dr Josep Trueta, Girona 17007, Spain

[2] CIBER Fisiopatol Obesidad, Girona 17007, Spain

[3] Kings Coll London, London Sch Med, Guys Hosp, Metab Unit, London SE1 9RT, England

[4] Kings Coll London, London Sch Med, Guys Hosp, Dept Diabet Endocrinol & Nutr, London SE1 9RT, England

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2008年 / 19卷 / 01期

关键词：

D O I：

10.1016/j.tem.2007.10.004

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Recent evidence has disclosed previously unrecognized links among insulin resistance, obesity, circulating immune markers, immunogenetic susceptibility, macrophage function and chronic infection.. Genetic variations leading to altered production or function of circulating innate immune proteins, cellular pattern-recognition receptors and inflammatory cytokines have been linked with insulin resistance, type 2 diabetes, obesity and atherosclerosis. Cellular innate immune associations with obesity and insulin resistance include increased white blood cell count and adipose tissue macrophage numbers. The innate immune response is modulated possibly by both predisposition (genetic or fetal programming), perhaps owing to evolutionary pressures caused by acute infections at the population level (pandemics), and chronic low exposure to environmental products or infectious agents. The common characteristics shared among innate immunity activation, obesity and insulin resistance are summarized.

引用

页码：10 / 16

页数：7

共 59 条

[1]

Genetics of Type 2 diabetes [J].

Barroso, I .

DIABETIC MEDICINE, 2005, 22 (05) :517-535

[2]

Prospective analysis of mannose-binding lectin genotypes and coronary artery disease in American Indians - The Strong Heart Study [J].

Best, LG ;

Davidson, M ;

North, KE ;

MacCluer, JW ;

Zhang, Y ;

Lee, ET ;

Howard, BV ;

DeCroo, S ;

Ferrell, RE .

CIRCULATION, 2004, 109 (04) :471-475

[3]

Innate immunity: an overview [J].

Beutler, B .

MOLECULAR IMMUNOLOGY, 2004, 40 (12) :845-859

[4]

Islet autoantibodies in clinically diagnosed type 2 diabetes: prevalence and relationship with metabolic control (UKPDS 70) [J].

Davis, TME ;

Wright, AD ;

Mehta, ZM ;

Cull, CA ;

Stratton, IM ;

Bottazzo, GF ;

Bosi, E ;

Mackay, IR ;

Holman, RR .

DIABETOLOGIA, 2005, 48 (04) :695-702

[5]

The epidemiology of low-grade chronic systemic inflammation and type 2 diabetes [J].

Duncan, Bruce B. ;

Schmidt, Maria Ines .

DIABETES TECHNOLOGY & THERAPEUTICS, 2006, 8 (01) :7-17

[6]

Troglitazone reduces hyperglycaemia and selectively acute-phase serum proteins in patients with Type II diabetes [J].

Ebeling, P ;

Teppo, AM ;

Koistinen, HA ;

Viikari, J ;

Rönnemaa, T ;

Nissén, M ;

Bergkulla, S ;

Salmela, P ;

Saltevo, J ;

Koivisto, VA .

DIABETOLOGIA, 1999, 42 (12) :1433-1438

[7]

Impact of infectious burden on extent and long-term prognosis of atherosclerosis [J].

Espinola-Klein, C ;

Rupprecht, HJ ;

Blankenberg, S ;

Bickel, C ;

Kopp, H ;

Rippin, G ;

Victor, A ;

Hafner, G ;

Schlumberger, W ;

Meyer, J .

CIRCULATION, 2002, 105 (01) :15-21

[8]

Dyslipidemia and inflammation:: an evotutionary conserved mechanism [J].

Esteve, E ;

Ricart, W ;

Fernández-Real, JM .

CLINICAL NUTRITION, 2005, 24 (01) :16-31

[9]

DEMONSTRATION OF A RELATIONSHIP BETWEEN WHITE BLOOD-CELL COUNT, INSULIN RESISTANCE, AND SEVERAL RISK-FACTORS FOR CORONARY HEART-DISEASE IN WOMEN [J].

FACCHINI, F ;

HOLLENBECK, CB ;

CHEN, YN ;

CHEN, YDI ;

REAVEN, GM .

JOURNAL OF INTERNAL MEDICINE, 1992, 232 (03) :267-272

[10]

Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin [J].

Fernandez-Real, J. M. ;

Straczkowski, M. ;

Vendrell, J. ;

Soriguer, F. ;

del Pulgar, S. Perez ;

Gallart, L. ;

Lopez-Bermejo, A. ;

Kowalska, I. ;

Manco, M. ;

Cardona, F. ;

Garcia-Gil, M. M. ;

Mingrone, G. ;

Richart, C. ;

Ricart, W. ;

Zorzano, A. .

DIABETOLOGIA, 2006, 49 (10) :2402-2411

← 1 2 3 4 5 6 →