Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer

被引：48

作者：

Clendenen, Tess V. ^{[2
]}

Arslan, Alan A. ^{[1
,2
,3
]}

Koenig, Karen L. ^{[2
]}

Enquist, Kerstin ^{[4
]}

Wirgin, Isaac ^{[2
]}

Agren, Asa ^{[4
]}

Lukanova, Annekatrin ^{[5
]}

Sjodin, Hubert ^{[4
]}

Zeleniuch-Jacquotte, Anne ^{[2
,3
]}

Shore, Roy E. ^{[6
]}

Hallnians, Goran ^{[4
]}

Toniolo, Paolo ^{[1
,2
,3
]}

Lundin, Eva ^{[7
]}

机构：

[1] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Environm Med, New York, NY 10016 USA

[3] NYU, Inst Canc, New York, NY 10016 USA

[4] Umea Univ, Dept Publ Hlth & Clin Med Nutr Res, Umea, Sweden

[5] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[6] Radiat Effects Res Fdn, Hiroshima, Japan

[7] Umea Univ, Dept Med Biosci Pathol, Umea, Sweden

来源：

CANCER LETTERS | 2008年 / 260卷 / 1-2期

关键词：

vitamin D receptor; genetic variants; ovarian neoplasms; epidemiology; prospective cohorts;

D O I：

10.1016/j.canlet.2007.11.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The vitamin D receptor (VDR) is a critical mediator of the cellular effects of vitamin D. The associations between four common VDR polymorphisms (BSMI, APAI, TAQI, and FOKI) and risk of epithelial ovarian cancer (EOC) were assessed in a case-control study nested within two prospective cohorts. One hundred seventy incident cases of EOC and 323 individually matched controls were genotyped. Overall, no associations were observed in genotype analyses. Haplotypes combining three SNPs in high linkage disequilibrium (BSMI, APAI, and TAQI) were also not associated with risk. These observations do not support a role for BSMI, APAL TAQI, and FOKI polymorphisms in epithelial ovarian cancer in a predominantly Caucasian population. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：209 / 215

页数：7

共 20 条

[1]

[Anonymous], CANC FACTS FIG 2007

[2] A vitamin D receptor gene polymorphism in the translation initiation codon: Effect on protein activity and relation to bone mineral density in Japanese women [J].

Arai, H ;

Miyamoto, KI ;

Taketani, Y ;

Yamamoto, H ;

Iemori, Y ;

Morita, K ;

Tonai, T ;

Nishisho, T ;

Mori, S ;

Takeda, E .

JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (06) :915-921

[3] Vitamin D and cancer [J].

Bouillon, Roger ;

Eelen, Guy ;

Verlinden, Lieve ;

Mathieu, Chantal ;

Carmeliet, Geert ;

Verstuyf, Annemieke .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2006, 102 (1-5) :156-162

[4] APAI DIMORPHISM AT THE HUMAN VITAMIN-D RECEPTOR GENE LOCUS [J].

FARACO, JH ;

MORRISON, NA ;

BAKER, A ;

SHINE, J ;

FROSSARD, PM .

NUCLEIC ACIDS RESEARCH, 1989, 17 (05) :2150-2150

[5]

FORD D, 1995, AM J HUM GENET, V57, P1457

[6] A second generation human haplotype map of over 3.1 million SNPs [J].

Frazer, Kelly A. ;

Ballinger, Dennis G. ;

Cox, David R. ;

Hinds, David A. ;

Stuve, Laura L. ;

Gibbs, Richard A. ;

Belmont, John W. ;

Boudreau, Andrew ;

Hardenbol, Paul ;

Leal, Suzanne M. ;

Pasternak, Shiran ;

Wheeler, David A. ;

Willis, Thomas D. ;

Yu, Fuli ;

Yang, Huanming ;

Zeng, Changqing ;

Gao, Yang ;

Hu, Haoran ;

Hu, Weitao ;

Li, Chaohua ;

Lin, Wei ;

Liu, Siqi ;

Pan, Hao ;

Tang, Xiaoli ;

Wang, Jian ;

Wang, Wei ;

Yu, Jun ;

Zhang, Bo ;

Zhang, Qingrun ;

Zhao, Hongbin ;

Zhao, Hui ;

Zhou, Jun ;

Gabriel, Stacey B. ;

Barry, Rachel ;

Blumenstiel, Brendan ;

Camargo, Amy ;

Defelice, Matthew ;

Faggart, Maura ;

Goyette, Mary ;

Gupta, Supriya ;

Moore, Jamie ;

Nguyen, Huy ;

Onofrio, Robert C. ;

Parkin, Melissa ;

Roy, Jessica ;

Stahl, Erich ;

Winchester, Ellen ;

Ziaugra, Liuda ;

Altshuler, David ;

Shen, Yan .

NATURE, 2007, 449 (7164) :851-U3

[7] Sunlight and mortality from breast, ovarian, colon, prostate, and non-melanoma skin cancer: a composite death certificate based case-control study [J].

Freedman, DM ;

Dosemeci, M ;

McGlynn, K .

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2002, 59 (04) :257-262

[8] Cardiovascular disease and diabetes in the Northern Sweden Health and Disease Study Cohort -: evaluation of risk factors and their interactions [J].

Hallmans, G ;

Ågren, Å ;

Johansson, G ;

Johansson, A ;

Stegmayr, B ;

Jansson, JH ;

Lindahl, B ;

Rolandsson, O ;

Söderberg, S ;

Nilsson, M ;

Johansson, I ;

Weinehall, L .

SCANDINAVIAN JOURNAL OF PUBLIC HEALTH, 2003, 31 :18-24

[9] Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease [J].

Holick, MF .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2004, 80 (06) :1678S-1688S

[10] Accounting for haplotype uncertainty in matched association studies: A comparison of simple and flexible techniques [J].

Kraft, P ;

Cox, DG ;

Paynter, RA ;

Hunter, D ;

De Vivo, I .

GENETIC EPIDEMIOLOGY, 2005, 28 (03) :261-272

← 1 2 →