5-aryl thiazolidine-2,4-diones as selective PPAR-γ agonists

被引：34

作者：

Koyama, H

Boueres, JK

Han, W

Metzger, EJ

Bergman, JP

Gratale, DF

Miller, DJ

Tolman, RL

MacNaul, KL

Berger, JP

Doebber, TW

Leung, K

Moller, DE

Heck, JV

Sahoo, SP

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Metab Disorders Diabet, Rahway, NJ 07065 USA

[3] Merck Res Labs, Dept Drug Metab, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(03)00257-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 5-aryl thiazolidine-2,4-diones containing 4-phenoxyphenyl side chains was designed, synthesized, and evaluated for PPAR agonist activities. One such compound 28 exhibited comparable levels of glucose correction to rosiglitazone in the db/db mouse type 2 diabetes animal model. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1801 / 1804

页数：4

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